Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2009, Vol. 31 ›› Issue (6): 728-734.doi: 10.3881/j.issn.1000-503X.2009.06.015

• Original Articles • Previous Articles     Next Articles

Association between Monoamine Oxidase A Gene and Major Depression in Chinese Han Population

ZHANG Jie-xu1;CHEN Yan-bo1;ZHANG Ke-rang2;XU Qi1;SHEN Yan1   

  1. 1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005, China
    2Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2009-10-09 Revised:1900-01-01 Online:2009-12-30 Published:2009-12-30
  • Contact: XU Qi

Abstract: ABSTRACT:Objective To explore the association between monoamine oxidase A (MAOA) variable number tandem repeat (VNTR) polymorphism and major depression in Chinese Han population. Methods Polymerase chain reaction was used to genotype MAOA VNTR polymorphism. A total of 512 major depression patients and 566 normal controls were recruited in our study. These patients were also assessed using the 14-item Hamilton anxiety scale. Results The allele frequency of MAOA VNTR was not significantly different between the male/female major depression patients and the normal controls. Compared with the normal controls, MAOA VNTR genotype was significantly more frequent in female major depression patients (P=0.002), but not in male patients (P=0.17). MAOA VNTR-L carrier was also associated with “fear” symptom in female patients (P=0.0056). ConclusionMAOA gene is associated with the major depression in Chinese Han population, especially among female patients.

Key words: major depression, monoamine oxidase a cene, variable number tandem repeat, damilton anxiety scale