Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2010, Vol. 32 ›› Issue (2): 157-161.doi: 10.3881/j.issn.1000-503X.2010.02.006

• Original Articles • Previous Articles     Next Articles

Roles of Hypertension and Serum Leptin in Obstructive Sleep Apnea Hypopnea Syndrome

HUANG Rong1;XIAO Yi1;ZHONG Xu1;LI Ming2;HUANG Xi-zhen1   

  1. 1Department of Respiratory Medicine,2Department of Endocrinology, PUMC Hospital,
    CAMS and PUMC,Beijing 100730,China
  • Received:2010-01-05 Revised:1900-01-01 Online:2010-04-30 Published:2010-04-30
  • Contact: XIAO Yi

Abstract: ABSTRACT:Objective To explore the roles of hypertension and serum leptin in obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Totally 60 patients with OSAHS (OSAHS group) and 40 age- and body mass index (BMI)-matched non-OSAHS individuals (non-OSAHS group) were enrolled in this study. The neck circumference (NC), waist/hip rate (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), leptin, fasting blood glucose (FBG), triglyceral (TG), cholesterol (Chol), and true insulin (TI) were measured before and after sleep . The correlations between hypertension/serum leptin level and OSAHS were analyzed. Results The blood pressure(in the morning), especially DBP was significantly higher in OSAHS group than in non-OSAHS control group[(89.75±2.04) mmHg vs.(81.63±1.91) mmHg, P<0.01]. DBP in OSAHS group was positively correlated with serum leptin and apnea hypopnea index (AHI) (r=0.282, P<0.05; r=0.318, P<0.01). Logistic regression analysis showed that BMI (P=0.029), heart rate in the morning (P =0.030), and leptin (P=0.049) were independently correlated with the development of hypertension. Conclusions OSAHS may independantly affect blood pressure, especially DBP, after waking up. BMI,HR in the morning,and serum leptin may be the independent correlates of hypertension.

Key words: obstructive sleep apnea dypopnea syndrome, dypertension, leptin