［1］Silverberg DS,Oksenberg A,Iaina A. Sleep-related brea- thing disorders as a major cause of essential hypertension: fact or fiction［J］? Curr Opin Nephrol Hypertens， 1998，7(4)：353-357.
［2］Nieto F,Young T, Palta M, et al. Association of sleep-disordered breathing, sleep apnea and hypertension in a large community based study. Sleep Heart Health Study［J］. JAMA, 2000，283(14)：1829-1836.
［3］Campos-Rodriguez F, Grilo-Reina A, Perez-Ronchel J，et al. Effect of continuous positive airway pressure on ambulatory BP in patients with sleep apnea and hypertension: a placebo-controlled trial［J］. Chest，2006，129(6)：1459-1467.
［4］Pelleymounter MA, Cullen MH, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice［J］. Science, 1995, 269(5223):540-543.
［5］Haynes WG. Role of leptin in obesity-related hypertension［J］. Exp Physiol, 2005, 90(5):683-688.
［6］Ai-Hazimi AM, Syiamic AY. Relationship between plasma angiotension Ⅱ, leptin and arterial blood pressure［J］. Saudi Med J, 2004, 25(9):1193-1198.
［7］Iber C,Ancoli-Israel S,Chesson A,et al. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specification［M］. Westchester, IL：American Academy of Sleep Medicine, USA, 2007：45-46.
［8］Martínez-García MA, Gómez-Aldaraví R, Martínez TG，et al. Sleep-disordered breathing in patients with difficult-to-control hypertension［J］. Arch Bronco Pneumol，2006，42(1)：14-20.
［9］Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension［J］. N Engl J Med，2000，342(19)：1378-1384.
［10］Alajmi M, Mulgrew AT, Fox J, et al. Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: a meta-analysis of randomized controlled trials［J］. Lung, 2007，185(2):67-72.
［11］Hoffstein V, Mateika J. Evening-to-morning blood pressure variations in snoring patients with and without obstructive sleep apnea［J］. Chest, 1992，101(2)：379-384.
［12］Stradling JR, Barbour C, Glennon J, et al. Which aspects of breathing during sleep influence the overnight fall of blood pressure in a community population［J］? Thorax, 2000, 55(5):393-398.
［13］Leuenberger UA, Brubaker D, Quraishi S, et al. Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans［J］. Auton Neurosci, 2005, 121(1-2):87-93.
［14］Rey S, Del Rio R, Iturriaga R. Contribution of endothelin-1 and endothelin A and B receptors to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia［J］. Adv Exp Med Biol,2008, 605:228-232.
［15］Loredo JSMG,Ziegler S, Ancoli-Israel P,et al. Relationship of arousals from sleep to sympathetic nervous system activity and obstructive sleep apnea［J］. Chest, 1999, 116（3）:655-659.
［16］Schulz R,Hummel C,Heinemann S,et al. Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia［J］.Am J Respir Crit Care Med, 2002, 165（1）:67-70.
［17］Trzepizur W, Gagnadoux F, Abraham P，et al. Microvascular endothelial function in obstructive sleep apnea: impact of continuous positive airway pressure and mandibular advancement［J］. Sleep Med， 2009，10(7)：746-752.
［18］Khayat RN, Przybylowski T, Meyer KC, et al. Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans［J］. J Appl Physiol，2004，97(2)：635-640.
［19］Shek EW,Brands MW,Hall JE. Chronic leptin infusion increases arterial pressure［J］. Hypertension， 1998，31（1pt2）:409-414.
［20］Ogawa Y, Masuzaki H, Aizawa M, et al. Blood pressure elevation in transgenic mice over-expressing leptin, the obese gene product［J］. J Hypertens，1998，16(Suppl 2):7.
［21］Haynes WG. Role of leptin in obesity-related hypertension［J］. Exp Physiol, 2005, 90(5):683-688.
［22］Nakamura Y, Ueshima H, Okuda N,et al. Relation of serum leptin to blood pressure of Japanese in Japan and Japanese-Americans in Hawaii［J］. Hypertension，2009，54(6)：1416-1422.
［23］Philips BG,Kato M,Narkiewicz K,et al. Increases in leptin levels,sympathetic drive,and weight gain in obstructive sleep apnea［J］. Am J Physiol Heart Circ Physiol，2000，279(1):234-237.
［24］Haynes WG, Morgan DA, Walsh SA, et al. Receptor mediated regional sympathetic nerve activation by leptin［J］. J Clin Invest，1997，100（2）:270-278.
［25］Rahmouni K, Haynes WG, Mark Al, et al. Cardiovascular and sympathetic effects of leptin［J］. Curr Hypertens Rep，2002，4（2）:119-125.
［26］Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia［J］. J Clin Endocrinol Metab，2000，85（3）:1151-1158.
|
Acta Academiae Medicinae Sinica
