Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (2): 169-174.doi: 10.3881/j.issn.1000-503X.2011.02.014

• Original Articles • Previous Articles     Next Articles

T2 Mapping of Articular Cartilage in Knee OsteoarthritisUsing A Magnetic Resonance Staging

HU Na1,2, ZHANG Yan2, SHENG Min2,WU Zhi-hong3, JIN Jin3, BAO Fei4,MENG Wei2, XU Jin2, JIANG Bo2, LIU Dong2, JIN Zheng-yu2   

  1. 1Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China 2Department of Radiology, 3Department of Orthopedics, 4Department of Acupuncture Moxibustion, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2010-01-14 Online:2011-04-10 Published:2011-04-10
  • Contact: JIN Zheng-yu Tel: 010-65295441 E-mail:jin_zhengyu@163.com

Abstract: Objective To evaluate T2 mapping of articular cartilage in knee osteoarthritis (OA). Methods Totally 38 healthy subjects (group H) and 53 OA patients received scoring with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and underwent T2 mapping of tibiofemoral articular cartilages. The T2 values in 10 subregions of the cartilages were measured. Patients in the OA group were further divided into OA1 group and OA2 group using the modified Magnetic Resonance Recht Grading System. In OA group, the fat-suppressed three-dimensional fast spoiled gradient echo MRI was performed to obtain the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The differences of T2 values among group H, group OA1, and group OA2 were compared. The correlation between T2 value and WORMS/WOMAC scores was analyzed. The intra- and inter-observer reproducibility of measurement was calculated. Results The T2 values in all the subregions ranged 43.9-53.6ms in group H, 41.1-55.0 ms in group OA1, and 45.6-56.1ms in group OA2. T2 values in group OA2 were significantly higher in central medial femoral subregion, central medial, and lateral tibial subregions compared with group H, also significantly higher in central medial femoral subregion, anterior and central medial tibial subregions compared with group OA1 (P<0.05). T2 values were significantly correlated with WORMS scores (R=0.307-0.811, P<0.01) except in posterior lateral femoral subregion, but not with WOMAC scores. The correlation coefficients for intra- and inter-observer measurement showed good reproducibility (R>0.740, P<0.05) except in anterior lateral tibial subregion for inter-observer of measurement. Conclusion T2 mapping can differentiate the OA severity of knee cartilage using a magnetic resonance staging, and therefore can be a sensitive technique for monitoring the severity of OA.

Key words: knee joint, osteoarthritis, articular cartilage, magnetic resonance imaging, T2 mapping

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