Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (2): 189-193.doi: 10.3881/j.issn.1000-503X.2011.02.018

• Original Articles • Previous Articles     Next Articles

Effects of Drag-reducing Polymers on Microcirculation of Normal Rat Hindlimb Skeletal Muscle

 HU   Feng, CHA  Dao-Gang, CHEN  Xiang-Hui, DU  Rong-Sheng, ZHOU  Bing-Jie, LIU  Yi-Li   

  1. Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2010-05-04 Online:2011-04-10 Published:2011-04-10
  • Contact: ZHA Dao-gang Tel: 020-62787390

Abstract: Objective To observe the effects of polyethylene oxide (PEO) on microcirculation of normal rat hindlimb skeletal muscle. Methods Sixteen male Wistar rats were anesthetized and equally and randomly divided into PEO group (administered with 10 ppm PEO solution) and control group (administered with equal volume of normal saline). The PEO solution or saline was separately injected through the caudal vein at a constant rate of 5 ml/h for 20 minutes. Using short axis view at right mid thigh region, contrast-enhanced ultrasonography was performed before and after the administration of solution. Electrocardiogram, blood pressure, and central venous pressure were also monitored. Results In the PEO group, after the administration of PEO, microcirculation capillary volume increased from (20.78±2.63) dB to (22.40±1.94) dB (P=0.023), red blood cell velocity from (0.27±0.08) s-1to (0.35±0.13) s-1(P=0.010), and capillary blood flow from (5.65±1.81) dB/s to (7.91±3.28) dB/s (P=0.013). In the control group, there were no significant changes in microcirculation capillary volume, red blood cell velocity, and capillary blood flow (all P>0.05) after the injection of normal saline. The changes of heart rates, blood pressures and central venous pressure were not significant after the administration of either PEO or saline (all P>0.05). Conclusion PEO can remarkably increase capillary volume, red blood cell velocity, and capillary blood flow in normal rat hindlimb skeletal muscle

Key words: drag-reducing polymers, polyethylene oxide, contrast-enhanced ultrasonography, microcirculation

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