Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (3): 299-305.doi: 10.3881/j.issn.1000-503X.2011.03.018

• Original Articles • Previous Articles     Next Articles

Association of STEAP4 Genetic Polymorphisms with Insulin Resistance in Uygur Chinese General Population

GUO Yan-ying1, 2, ZHOU Ling3, YAO Xiao-guang3 , YAN Zhi-tao3, WANG Hong-mei3   

  1. 1Postdoctoral Research Station, School of Basic Medicine, CAMS and PUMC, Beijing 100005, China
    2Postdoctoral Research Station,the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
    3Center of Diagnosis, Treatment and Research of Hypertension, Department of Hypertension, the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
    4National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences,CAMS and PUMC, Beijing 100005, China
  • Received:2010-10-29 Revised:2011-07-01 Online:2011-07-01 Published:2011-07-01
  • Contact: LI Nan-fang E-mail:Lnanfang@yahoo.com.cn
  • Supported by:

    the National Natural Sciences Foundation of China(30850006) and Foundation of People's Hospital of Xinjiang Uygur Autonomous Region (20080106)

Abstract: Objective To explore the relationship between six-transmembrane epithelial antigen of prostate 4 (STEAP4) genetic polymorphisms and insulin resistance (IR) in Uygur Chinese general population. Methods In this cross-sectional study on the metabolic diseases (e.g. obesity) among Uygur Chinese in Hetian, Xinjiang, China,from January to February 2007, 2127 Uygur individuals were enrolled. The sample size for IR subjects [homeostasis model assessment for insulin resistance (HOMA-IR) ≥2.3 65%] was 669, whereas that for non-IR controls was 664 (HOMA-IR≤1.335%). STEAP4 gene was sequenced in 50 Uygur Chinese individuals with IR (HOMA-IR≥2.3). The representative variations were selected from the population based on a r2 cutoff of 0.8 and a minor allele frequency of >5% for case-control study. Results Totally 16 variations including 10 novel variations (no reported in dbSNP) were identified in 50 Uygur individuals with IR. 7414 G/A (rs8122)(P/Pc=0.004/0.012)and 224A/G (rs1981529, Gly75Asp)(P/Pc=0.015/0.045)variations were significantly correlated with IR phenotype in Uygur subjects. As shown by multiple linear regression analysis, the mean values of waist circumference (WC) (P/Pc=0.032/0.256), body mass index (BMI) (P/Pc=0.004/0.032), HOMA-IR (P/Pc=0.010/0.08), and fasting insulin (P/Pc=0.023/0.184) among A (protection) allele carriers of rs8122 and the mean values of WC (P/Pc=0.005/0.040) and BMI (P/Pc=0.002/0.016) among G (protection) allele carriers of rs1981529 gradually declined. Haplotype 1 (rs8122 G- rs1981529 A- rs34741656 G) was significantly associated with a higher prevalence of IR (Permutation P=0.021). Conclusion STEAP4 genetic variations are likely to be associated with obesity-related insulin resistance in Uygur Chinese general population.

Key words: genetic epidemiology, genetic association study, insulin resistance, Uygur

CLC Number: