Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (4): 427-431.doi: 10.3881/j.issn.1000-503X.2011.04.015

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Clinical Significance of Tissue Factor and Vascular Endothelial Growth Factor Expressions on CD14+ Monocytes in Patients with Non Hodgkin Lymphoma

WANG Hongxia1, LI Xiumei2, HAN Xiuhua2, JIANG Yajun2, ZHU Guihua2, ZHUANG Wanchuan2   

  1. 1Department of Pathology, Lianyungang Hospital of Xuzhou Medical College, First Peoples Hospital of Lianyungang City, Lianyungang, Jiangsu 222002, China
    2Department of Hemotology, Lianyungang Hospital of Bengbu Medical College, Second Peoples Hospital of Lianyungang,Lianyungang, Jiangsu 222002, China
  • Received:2010-09-19 Revised:2011-09-05 Online:2011-08-01 Published:2011-08-01
  • Contact: JIANG Ya-jun

Abstract: Objective To explore the values of tissue factor (TF) and vascular endothelial growth factor (VEGF) expressions on peripheral CD14+ monocytes in disease assessment, prognosis, and short-term efficacy evaluation of non-Hodgkin lymphoma (NHL) patients. Methods TF and VEGF expressions on CD14+ monocytes in 47 NHL patients (disease group) before chemotherapy and after 4 chemotherapy cycles and in 30 healthy subjects (control group) were detected by flow cytometry, and the potential relationship among TF, VEGF, International Prognostic Index (IPI), and short-term efficacy were analyzed. Results TF and VEGF expressions on CD14+ monocytes in disease group were significantly higher than those in control group (all P1 (n=16) groups were significantly higher than those in Ann Arbor stage Ⅱ(n=6), asymptomatic (n=25), LDH normal (n=26), ECOG score 0-1 (n=35) and extranodal lesions ≤1 (n=31) groups, respectively (all P0.05).Conclusion The high expressions of TF and VEGF on peripheral CD14+ monocytes can be useful markers in disease assessment, prognosis evaluation and short-term efficacy observation of NHL patients."

Key words: non-Hodgkin lymphoma, monocytes, tissue factor, vascular endothelial growth factor, International Prognostic Index

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