Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (5): 489-494.doi: 10.3881/j.issn.1000-503X.2011.05.003

• Original Articles • Previous Articles     Next Articles

Pharmacokinetic and Pharmacodynamic Characteristics of the Domestic Sevoflurane for Transabdominal Hysterectomy

ZHANG Yu, ZHU Bo, LIN Si-fang, YE Tie-hu, GONG Zhi-yi   

  1. Department of Anesthesiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2011-03-30 Revised:2011-10-28 Online:2011-10-28 Published:2011-10-28
  • Contact: ZHU Bo E-mail:zhuboxx@yahoo.com.cn

Abstract: Objective To evaluate the clinical efficacy of domestic sevoflurane by comparing the pharmacokinetic and pharmacodynamic characteristics of domestic sevoflurane and an imported product. Methods Eighty patients undergoing general anesthesia for transabdominal hysterectomy were equally randomized into domestic sevoflurane group and imported sevoflurane group. The following data were recorded and compared: vital signs; change of sevoflurane concentrations in the induction period and recovery period; the time when inhaled sevoflurane concentration reached half of the pre-set concentration of the vaporizer; the time when the end-tidal sevoflurane concentration reached half of the pre-set concentration of the vaporizer; the time when the end-tidal sevoflurane concentration reached half of inhaled sevoflurane concentration; the time of the end-tidal sevoflurane concentration reached 0.8 MAC in the induction period; the recovery time; the extubation time; and time to recovery of consciousness. Results The general conditions of the two groups were not significantly different. The pharmacokinetic and pharmacodynamics parameters at the intra-operative time points as well as the minimal alveolar concentration, the inspired and end-tidal sevoflorane concentrations, and the time to recovery of consciousness also showed no significant differences between the two groups. Conclusion The domestic sevoflurane has similar pharmacokinetic and pharmacodynamic characteristics as the imported products. It can serve as a cost-effective product for transabdominal hysterectomy.

Key words: sevoflurane, pharmacokinetics, pharmacodynamics, medical cost

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