Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (5): 533-537.doi: 10.3881/j.issn.1000-503X.2011.05.011

• Original Articles • Previous Articles     Next Articles

Relationship between rs3865418 Polymorphism of Neural Precursor Cell Expressed Developmentally Downregulated 4 Like Gene and Obesity in Kazakh General Population

WANG Hong-mei1, HONG Jing2, LUO Wen-li2, CHANG Jian-hang2, YAO Xiao-guang1, LI Nan-fang2   

  1. 1Graduate School of Xinjiang Medical University, Urumqi 830054, China; 2Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, Urumqi 830001, China
  • Received:2010-10-12 Revised:2011-10-28 Online:2011-10-28 Published:2011-10-28
  • Contact: LI Nan-fang E-mail:lnanfang@yahoo.com.cn
  • Supported by:
    Supported by the Open Research Grant, Laboratory of Hypertension Research Xinjiang Uygur Autonomous Region in China(XJYS0906-2009-01)

Abstract: Objective To investigate the relationships between rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene and obesity in Kazakh general population. Methods Based on a cross-sectional epidemiological study in a Kazakh general population, a case-control study was conducted. The rs3865418 polymorphism in a Kazakh general population (856 subjects, including 364 males and 492 females; 478 in obesity group and 378 in normal control group) was genotyped by TaqMan polymerase chain reaction (PCR), and the relationship between rs3865418 polymorphism and obesity was analyzed. Results The rs3865418 polymorphism was successfully genotyped in 851 Kazakh subjects. The distribution of the genotypes and alleles of rs3865418 polymorphism did not differ significantly between the obesity group and normal control group in terms of general populations, males, and females (all P>0.05). The waist circumference showed a tendency of C/C>C/T>T/T in males and C/C<C/T<T/T in females, but without statistical significance(P>0.05). Conclusions The rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene may not be associated with obesity in Kazakh general population. In other words, it is not a predisposing factor for obesity in Kazakh.

Key words: neural precursor cell expressed developmentally downregulated 4-like, obesity, Kazakh, rs3865418

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