Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (5): 575-581.doi: 10.3881/j.issn.1000-503X.2011.05.019

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Research Advances in MicroRNA in Pancreatic Ductal Adenocarcinoma

YU Chun-kai, YU Shuang-ni, LU Zhao-hui, CHEN Jie   

  1. Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2011-04-06 Revised:2011-10-28 Online:2011-10-28 Published:2011-10-28
  • Contact: CHEN Jie
  • Supported by:
    Supported by the National Nature Sciences Foundation of China(30471970) and the National Key Technology R&D Program in the 11th Five Year Plan of China (2006BAI02A14)

Abstract: MicroRNA (miRNA), small non-coding RNA consisted of 19-24 nucleotides, are able to regulate gene expression at the post-transcriptional level. The aberrant expressions of miRNA have been found in various cancers and contribute to carcinogenesis by promoting the expression of proto-oncogenes or by inhibiting the expression of tumor suppressor genes. miRNA are related closely with the oncogenesis, progression, and prognosis of tumors. The discovery of the aberrant expression of miRNA in pancreatic ductal adenocarcinoma (PDA) and its target genes are helpful for the understanding of the pathogenesis of PDA and for the early diagnosis and prediction of this disease. In this paper, we summarize the recent research advances in miRNA expression in PDA and its target genes and discuss the potential role of miRNA in the diagnosis, and treatment of PDA.

Key words: pancreatic ductal adenocarcinoma, microRNA;target gene, biomarker

CLC Number: