Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (6): 593-599.doi: 10.3881/j.issn.1000-503X.2011.06.002

• Original Articles • Previous Articles     Next Articles

Meta-analysis of the Association of Pro12Ala Polymorphism of Peroxisome Proliferator Activated Receptorγ Gene with Type 2 Diabetes in Chinese Han Population

GUO Wu-lan, TANG Yong, HAN Xue-yao, JI Li-nong   

  1. Department of Endocrinology,People's Hospital,Peking University,Beijing 100044, China
  • Received:2011-11-21 Revised:2012-01-04 Online:2011-12-20 Published:2011-12-20
  • Contact: JI Li-nong E-mail:jiln@bjmu.edu.cn
  • Supported by:

    Supported by the National Natural Sciences Foundation of China(30771031, 30570873) , the National High Technology Research and Development Program of China(863 Program) (2006AA02A409) , and the National Basic Research Program of China (973 Program) (2005CB523000)

Abstract: Objective To evaluate the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor γ(PPARγ) gene with type 2 diabetes (T2DM)in Chinese Han population. Methods The present investigation was carried out using the keywords “PPARγ”,“pparg”,“Pro12Ala”,“type 2 diabetes”, and“Chinese. The odds ratios(OR) for Ala12 used as the metric of choice were calculated in the dominant and additive model separately. The Meta-analysis was conducted by softeware STATA 11.0. Results (1) We identified 22 studies, of which 17 studies involving 3927 type 2 diabetes cases and 3364 controls fell into the inclusion criteria. The analysis indicated no significant inter-study heterogeneity and publication bias. (2) The frequencies of the minor allele Ala12 in type 2 diabetes and control groups were 4.8%and 4.6% respectively. (3) The combined overall OR of dominant and additive model calculated by fix-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism, were 0.95(95% CI:0.80,1.12) and 0.93(95% CI:0.79,1.09) respectively. Conclusion In this meta-analysis, the Pro12Ala gene variant (rs1801282) is not found to be associated with the susceptibility for type 2 diabetes in Chinese Han population.

Key words: peroxisome proliferator activated receptor, Pro12Ala, diabetes mellitus, type 2, Meta analysis

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