Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2011, Vol. 33 ›› Issue (6): 670-674.doi: 10.3881/j.issn.1000-503X.2011.06.017

• Original Articles • Previous Articles     Next Articles

Expression of Manganese Superoxide Dismutas in Colorectal Carcinoma and Its Relationship with Clinicopathological Findings

LI Xiao1, SUN Zi-qin1, WEI Zhi1, NIU Jing2, LIU Xiao-feng1, WANG Wei1   

  1. 1Department of Gastroenterology, General Hospital of Jinan Military Command, Jinan 250031, China; 2Department of Gastroenterology, Northern District Hospital of Qingdao, Qingdao, Shandong 266000, China
  • Received:2011-11-02 Revised:2012-01-04 Online:2011-12-20 Published:2011-12-20
  • Contact: SUN Zi-qin
  • Supported by:

    Supported by the Special Foundation of President of General Hospital of Jinan Military Command

Abstract: Objective To explore the expression of manganese superoxide dismutas (MnSOD) in colorectal carcinoma and its relationship with the clinicopathological findings. Methods The expressions of MnSOD in colorectal carcinoma, adenoma, and adjacent corresponding intestinal mucosal tissues were detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The relationship between MnSOD expression level in colorectal adenoma and clinical parameters was analyzed. Results The expression of MnSOD was negative in adjacent corresponding colorectal tissues. The positive expression rate of MnSOD was 44%(11/25)in colorectal adenoma and 76%(19/25)in colorectal carcinoma (P0.05). Conlusion The expression of MnSOD may be associated with the carcinogenesis and progression of colorectalcarcinoma, and therefore may be used as a new biomarker."

Key words: colorectal neolasma, manganese superoxide dismutas, imumunohistlchemistry, reverse transcription-polymerase chain reaction

CLC Number: