Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (1): 8-13.doi: 10.3881/j.issn.1000-503X.2012.01.002

• Original Articles • Previous Articles     Next Articles

Prevention of Restenosis in the Canine Coronary Stents through Local Delivery ofPaclitaxel Using the Double-balloon Perfusion Catheter

WANG Jin-da, YANG Ting-shu, SUN Zhi-jun, GUO Jun, TIAN Feng, CHEN Yun-dai   

  1. Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2011-12-01 Revised:2012-03-02 Online:2012-03-01 Published:2012-03-01
  • Supported by:

    Supported by the National High Technology Research and Development Program of China (863 Program)(2009AA02Z420)

Abstract: Objective To evaluate the safety and efficiency of local paclitaxel delivery using the double-balloon perfusion catheter to prevent restenosis in the canine coronary artery. Methods Twenty domestic canines underwent bare-mental stent implantation after ballon injure of the left coronary artery. A novel double-balloon perfusion catheter was used to deliver the drug locally in the canine coronary artery. In the treatment group (n=15),paclitaxel (10 ml, 20 μmol/L) was delivered using the double-balloon perfusion catheter before stent implantation. In the control group (n=5), 10 ml saline was delivered using the double-balloon perfusion catheter before stent implantation. The perfusion time in both groups was (26.45±5.18) s. Animals underwent coronary angiography and optical coherence tomography (OCT) 90 days after stent implantation and were sacrificed. Vessels were perfusion-fixed and morphometric analysis was performed using conventional techniques. Results Coronary angiography results showed restenosis rate in control group was significantly higher than that in treatment group (60% vs. 33.33%, P<0.05). The parameters of OCT showed in treatment group and control group: the neointimal thickness was (0.19±0.08)mm and (0.38±0.03)mm, the neointimal area was (1.52±0.49)mm2 and (2.51±0.47)mm2, the lumen area was (3.50±0.66)mm2 and (2.78±0.57)mm2,the extent of stenosis was (30.13±8.56)% and (47.40±4.50)%, and all the variances above were significantly different between the two groups (P<0.05). The histologic parameters showed in treatment group and control group: the neointimal thickness was (0.22±0.10)mm and (0.47±0.05)mm, the neointimal area was (1.85±0.78)mm2 and (3.43±0.25)mm2, the lumen area was (3.15±0.43)mm2 and (1.85±0.55)mm2,the extent of stenosis was (36.00±10.97)% and (65.40±8.23)%, and all the variances above were also significantly different between the two groups (P<0.05). The stents of both the groups were fully endothelialized. No thrombus or aneurysm was found in stents. Conclusion Local delivery of paclitaxel with the double-balloon perfusion catheter to prevent restenosis in coronary stents is safe and efficient.

Key words: bare-metal stent, local drug delivery, paclitaxel, restenosis, animal experiment

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