Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (2): 178-182.doi: 10.3881/j.issn.1000-503X.2012.02.015

• Abstracts • Previous Articles     Next Articles

Research Advances in Suppressor of Cytokine Signaling 3

LIN Na,YAO Xiao-guang,LI Nan-fang   

  1. Center of Hypertension, People’s Hospital of Xinjiang Uygur Autonomous Region,Institute of Xinjiang Hypertension, Urumqi 830001, China
  • Received:2012-04-28 Revised:2012-04-28 Online:2012-04-28 Published:2012-04-28
  • Contact: LI Nan-fang
  • Supported by:

    Supported by the National Natural Sciences Foundation of China (31060157)

Abstract: Suppressor of cytokine signaling(SOCS) 3, a novel type of cytokine signal transduction inhibitory molecules in family of SOCS, is mainly involved in Janus protein tyrosine kinase/signal transducer andantivator of transcription signaling pathway negative feedback regulation. It is involved in inflammation, oxidative stress, cell damage, and apoptosis. Meanwhile, it is closely related to atherosclerosis, obesity, glucose metabolism, insulin resistance, leptin, cancer, asthma, and rheumatic diseases. Therefore, SOCS-3 may become a therapeutic target of these diseases.

Key words: suppressor of cytokine signaling 3, inflammation, signal transduction, diseases