细胞因子信号转导抑制因子3的研究进展

doi:10.3881/j.issn.1000-503X.2012.02.015

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (2): 178-182.doi: 10.3881/j.issn.1000-503X.2012.02.015

• Abstracts • Previous Articles Next Articles

Research Advances in Suppressor of Cytokine Signaling 3

LIN Na，YAO Xiao-guang，LI Nan-fang

Center of Hypertension, People’s Hospital of Xinjiang Uygur Autonomous Region,Institute of Xinjiang Hypertension, Urumqi 830001, China

Received:2012-04-28 Revised:2012-04-28 Online:2012-04-28 Published:2012-04-28
Contact: LI Nan-fang E-mail:Lnanfang@yahoo.com.cn
Supported by:
Supported by the National Natural Sciences Foundation of China （31060157）

Abstract

Abstract: Suppressor of cytokine signaling(SOCS) 3, a novel type of cytokine signal transduction inhibitory molecules in family of SOCS, is mainly involved in Janus protein tyrosine kinase/signal transducer andantivator of transcription signaling pathway negative feedback regulation. It is involved in inflammation, oxidative stress, cell damage, and apoptosis. Meanwhile, it is closely related to atherosclerosis, obesity, glucose metabolism, insulin resistance, leptin, cancer, asthma, and rheumatic diseases. Therefore, SOCS-3 may become a therapeutic target of these diseases.

Key words: suppressor of cytokine signaling 3, inflammation, signal transduction, diseases

LIN Na，YAO Xiao-guang，LI Nan-fang. Research Advances in Suppressor of Cytokine Signaling 3[J].Acta Academiae Medicinae Sinica, 2012, 34(2): 178-182.

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