Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (3): 254-257.doi: 10.3881/j.issn.1000-503X.2012.03.012

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Correlation of T Lymphocyte Subsets with Blood Glucose Level and the First-Phase Insulin Secretion in Patients with Type 2 Diabetes Mellitus

ZHANG Qiu-ling, ZANG Shu-fei   

  1. Department of Endocrinology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China
  • Received:2011-11-15 Revised:2012-06-30 Online:2012-06-29 Published:2012-06-29

Abstract: Objective To explore the relationship between the T cell subsets and glucose level and first-phase insulin secretion function in patients with type 2 diabetes mellitus (T2DM). Methods We determined the oral glucose tolerance (OGTT), insulin release test(IRT), body mass index(BMI), glycohemoglobin A1c (HbA1c), T lymphocyte subsets (CD4+,CD8+), and activity of natural kill(NK) cell and ⊿I30/⊿G30 in 78 newly diagnosed T2DM patients, 60 impaired glucose tolerance (IGT) patients, and 60 normal controls. Results DM and IGT patients had significantly lower levels of CD4+, CD4+/CD8+ratio, activity of NK cell, and ⊿I30/⊿G30 and significantly higher levels of HbA1c and CD8+compared with normal controls(all P<0.05). Patients in DM group had significantly lower level of CD4+,⊿I30/⊿G30 and significantly higher levels of FBG and HbA1c compared with IGT group. There was no significant difference in terms of CD8+, CD4+/CD8+ratio, and activity of NK cell between IGT and DM groups, whereas CD4+ T cells were negatively correlated with FBG and HbA1c and positively with ⊿I30/⊿G30 . Multipul regression stepwise analysis showed that CD4+ was independently associated with HbA1c and ⊿I30/⊿G30. Conclusion T2DM patients tends to have disorders in cellular immunity, which is correlated with blood glucose level and the insulin secretion function.

Key words: type 2 diabetes mellitus, T lymphocyte subsets, insulin secretion function

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