Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (3): 262-266.doi: 10.3881/j.issn.1000-503X.2012.03.014

• Original Articles • Previous Articles     Next Articles

Validity of Auditory Verbal Learning Test in Diagnosis of Alzheimer's Disease

HONG Xia1, ZHANG Zhen-xin2, WU Li-yong3, SHI Li-li1, ZHAO Xiao-hui1, WEI Jing1   

  1. 1Department of Psychological Medicine, 2Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    3Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2011-10-26 Revised:2012-06-30 Online:2012-06-29 Published:2012-06-29

Abstract: Objective To assess the validity of World Health Organization-University of California-Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) in the diagnosis of Alzheimer's disease (AD). Methods Using WHO-UCLA AVLT, we assessed 183 AD patients (AD group) , 1283 subjects with normal cognitive status (normal control group), and 134 individuals suffered from other diseases easy to be confused with AD (confused control group). Results The AVLT score was 40.9±0.3 in normal control group, 30.7±0.9 in confused control group, 16.6±1.0 in mild AD group, and 10.2±1.2 in moderate AD group after adjustment for educational level, age, sex, and rural/urban residence (all P<0.05). With the 5th percentage of the overall score as the cutoff point, this tool showed a sensitivity of 86.3% and a specificity of 93.3%. Conclusion WHO-UCLA CVLT is highly sensitive and specific in the diagnosis of AD.

Key words: dementia, Alzheimer's disease, neuropsychological test, auditory verbal learning test

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