Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (3): 286-292.doi: 10.3881/j.issn.1000-503X.2012.03.020

• Abstracts • Previous Articles     Next Articles

TAR DNA Binding Protein-43 and Fused in Sarcoma/Translocated in Liposarcoma Protein in Two Neurodegenerative Diseases

WANG Xin-ning, CUI Li-ying   

  1. Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2011-06-15 Revised:2012-06-30 Online:2012-06-29 Published:2012-06-29

Abstract: TAR DNA binding protein-43(TDP-43) and fused in sarcoma/translocated in liposarcoma protein (FUS/TLS) have been found to be associated with two neurodegenerative diseases - amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TDP-43 and FUS/TLS lead to abnormal protein expressions, which result in altered RNA processing. The pathological changes of TDP-43 and FUS/TLS-associated ALS and FTD are similar. Although the interactions between ALS and FTD remain unknown, it is speculated that TDP-43 and FUS/TLS-associated neurodegenerative diseases may share similar pathogenesis.

Key words: TAR DNA binding protein-43, fused in sarcoma/translocated in liposarcoma protein, amyotrophic lateral sclerosis, frontotemporal dementia, RNA processing

CLC Number: