Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (4): 396-400.doi: 10.3881/j.issn.1000-503X.2012.04.016

• Original Articles • Previous Articles     Next Articles

Application Value of Apparent Diffusion Coefficient in Differentiation of Brain radiation-injuries and Glioma Recurrence

WANG Yu-lin1, LIU Meng-yu2, LI Jin-feng1, ZHANG Jun3, SUN Lu4, FENG Feng2, MA Lin1   

  1. 1Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China
    2Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    3Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China
    4Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2012-02-15 Revised:2012-08-31 Online:2012-08-30 Published:2012-08-30

Abstract: Objective To evaluate application value of apparent diffusion coefficient (ADC) in di- fferentiating brain radiation-injuries and glioma recurrence. Methods Totally 23 patients [18 men and 5 women aged 32 to 67 years (mean: 47 years)] with previously resected and irradiated glioma were examined by using a 3.0T MR Scanner, including conventional and diffusion weighted image (DWI) sequences. All the cases were proved by pathology or clinical follow-up. Postprocessing of ADC maps was performed by using Functool software (AW 4.3, GE Healthcare), and the regions of interest (ROIs) were manually drawn on ADC maps in the area corresponding to the contrast-enhancing area on post-contrast axial T1-weighted images, avoiding the hemorrhage or necrosis. The ADC values were calculated automatically. ADC values were measured 10 times in order to reduce errors, and mean ADC value, maximum ADC value, and minimum ADC value were acquired. Results Both recurrent glioma and irradiated necrosis tended to have hemorrhage, necrosis, and edema. The mean ADC value and maximum ADC value were lower in the recurrent tumor group than in the radiation-injuries group, but no statistical difference was achieved. However, the minimum ADC value was significantly lower in the recurrent tumor group than in the radiation-injuries group (P=0.016). Conclusion The minimum ADC value can be used as an useful tool in differentiating tumor recurrence from radiation-injuries.

Key words: diffusion weighted imaging, magnetic resonance imaging, apparent diffusion coefficient, radiation injuries, glioma recurrence

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