基于体素的多系统萎缩梯度回波横向弛豫率R2*分析

doi:10.3881/j.issn.1000-503X.2012.05.003

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (5): 450-454.doi: 10.3881/j.issn.1000-503X.2012.05.003

• Original Articles • Previous Articles Next Articles

Voxel-based Relaxometry of Transverse Relaxation Rate with Gradient Echo R2^* in Patients with Multiple System Atrophy

HOU Bo¹, YOU Hui¹, WANG Han², ZHAO Yan-ping³, JIANG Bo¹,SUN Hong-yi¹, CUI Li-ying², FENG Feng¹

¹Department of Radiology,²Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China³Department of Radiology, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Received:2012-07-16 Revised:2012-11-07 Online:2012-10-31 Published:2012-10-31
Supported by:
Supported by the National Natural Sciences Foundation of China（30670608）

Abstract

Abstract:

Objective To explore the transverse relaxation rate with gradient echo R2^* changes in patients with Parkinsonian variant of multiple system atrophy (MSA-P) with a voxel-based analysis of R2^* map. Methods Whole brain structural images and multi-echo T2^* weighted image were acquired in 27 patients with probable MSA-P and 24 healthy individuals. R2^* maps of the MSA-P were compared with the controls by voxel-based methods. Result Compared with the controls, MSA-P patients showed significant R2^* decrease bilaterally in brain stem, cerebellar hemispheres, insular lobe, temporal lobes, caudate nucleus, and corpus callosum (P<0.005). Conclusions R2^* can reveal the significant brain involvements of MSA-P. The introduction of gradient echo may increase the sensitivity, although the susceptible artifact may interfere the detection efficiency of R2^*.

Key words: multiple system atrophy, magnetic resonance imaging, relaxometry

CLC Number:

R445.2

HOU Bo,YOU Hui,WANG Han,ZHAO Yan-ping,JIANG Bo,SUN Hong-yi,CUI Li-ying,FENG Feng. Voxel-based Relaxometry of Transverse Relaxation Rate with Gradient Echo R2^* in Patients with Multiple System Atrophy[J].Acta Academiae Medicinae Sinica, 2012, 34(5): 450-454.

References

[1]Deoni SC. Quantitative relaxometry of the brain［J］. Top Magn Reson Imaging, 2010,21(2):101-113.
［2］Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy［J］. Neurology, 2008,71(9):670-676.
［3］Good CD, Johnsrude IS, Ashburner J, et al. A voxel-based morphometric study of ageing in 465 normal adult human brains［J］. Neuroimage, 2001,14(1 Pt 1):21-36.
［4］Specht K, Minnerop M, Muller-Hubenthal J, et al. Voxel-based analysis of multiple-system atrophy of cerebellar type: complementary results by combining voxel-based morphometry and voxel-based relaxometry［J］. Neuroimage, 2005,25(1):287-293.
［5］Minnerop M, Specht K, Ruhlmann J, et al. Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy a comparison between clinical subtypes and correlations with clinical parameters［J］. Neuroimage, 2007,36(4):1086-1095.
［6］Tzarouchi LC, Astrakas LG, Konitsiotis S, et al. Voxel-based morphometry and voxel-based relaxometry in parkinsonian variant of multiple system atrophy［J］. J Neuroimaging, 2010,20(3):260-266.
［7］侯波, 有慧, 王含, 等. 多系统萎缩弥散张量成像的基于体素分析［J］. 中国医学影像学杂志, 2012,20(5):363-367,371.
［8］Schwarz J, Weis S, Kraft E, et al. Signal changes on MRI and increases in reactive microgliosis, astrogliosis, and iron in the putamen of two patients with multiple system atrophy［J］. J Neurol Neurosurg Psychiatry, 1996,60(1):98-101.
［9］Konagaya M, Sakai M, Matsuoka Y, et al. Pathological correlate of the slitlike changes on MRI at the putaminal margin in multiple system atrophy［J］. J Neurol, 1999,246(2):142-143.
［10］Konagaya M, Sakai M, Matsuoka Y, et al. Multiple system atrophy with remarkable frontal lobe atrophy［J］. Acta Neuropathol, 1999,97(4):423-428.
［11］Wakabayashi K, Ikeuchi T, Ishikawa A, et al. Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matter［J］. J Neurol Sci, 1998,156(1):114-117.
［12］Wenning GK, Ben-Shlomo Y, Magalhaes M, et al. Clinicopathological study of 35 cases of multiple system atrophy［J］. J Neurol Neurosurg Psychiatry, 1995,58(2):160-166.
［13］Wenning GK, Tison F, Ben SY, et al. Multiple system atrophy: a review of 203 pathologically proven cases［J］. Mov Disord, 1997,12(2):133-147.
［14］Burn DJ, Jaros E. Multiple system atrophy: cellular and molecular pathology［J］. Mol Pathol, 2001,54(6):419-426.
［15］Ubhi K, Low P, Masliah E. Multiple system atrophy: a clinical and neuropathological perspective［J］. Trends Neurosci, 2011,34(11):581-590.
［16］Brenneis C, Seppi K, Schocke MF, et al. Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy［J］. Mov Disord, 2003,18(10):1132-1138.
［17］Minnerop M, Luders E, Specht K, et al. Callosal tissue loss in multiple system atrophy-a one-year follow-up study［J］. Mov Disord, 2010,25(15):2613-2620.
［18］Wang Y, Butros SR, Shuai X, et al. Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging［J］. AJNR Am J Neuroradiol, 2012,33(2):266-273.
［19］冯逢, 有慧, 胡凌, 等. 磁敏感加权成像鉴别多系统萎缩与特发性帕金森病的初步研究［J］. 中国医学影像技术, 2007,23(6):781-784.
［20］冯逢, 有慧, 王含, 等. 相位加权成像在多系统萎缩与帕金森病的鉴别诊断中的作用［J］. 中国医学科学院学报, 2009,31(2):129-133.
［21］Brooks DJ, Seppi K. Proposed neuroimaging criteria for the diagnosis of multiple system atrophy［J］. Mov Disord, 2009,24(7):949-964.

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Voxel-based Relaxometry of Transverse Relaxation Rate with Gradient Echo R2^* in Patients with Multiple System Atrophy