Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (5): 450-454.doi: 10.3881/j.issn.1000-503X.2012.05.003

• Original Articles • Previous Articles     Next Articles

Voxel-based Relaxometry of Transverse Relaxation Rate with Gradient Echo R2* in Patients with Multiple System Atrophy

HOU Bo1, YOU Hui1, WANG Han2, ZHAO Yan-ping3, JIANG Bo1,SUN Hong-yi1, CUI Li-ying2, FENG Feng1   

  1. 1Department of Radiology,2Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China3Department of Radiology, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • Received:2012-07-16 Revised:2012-11-07 Online:2012-10-31 Published:2012-10-31
  • Supported by:

    Supported by the National Natural Sciences Foundation of China(30670608)


Objective To explore the transverse relaxation rate with gradient echo R2* changes in patients with Parkinsonian variant of multiple system atrophy (MSA-P) with a voxel-based analysis of R2* map. Methods Whole brain structural images and multi-echo T2* weighted image were acquired in 27 patients with probable MSA-P and 24 healthy individuals. R2* maps of the MSA-P were compared with the controls by voxel-based methods. Result Compared with the controls, MSA-P patients showed significant R2* decrease bilaterally in brain stem, cerebellar hemispheres, insular lobe, temporal lobes, caudate nucleus, and corpus callosum (P<0.005). Conclusions R2* can reveal the significant brain involvements of MSA-P. The introduction of gradient echo may increase the sensitivity, although the susceptible artifact may interfere the detection efficiency of R2*.

Key words: multiple system atrophy, magnetic resonance imaging, relaxometry

CLC Number: