Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (5): 509-514.doi: 10.3881/j.issn.1000-503X.2012.05.013

• Original Articles • Previous Articles     Next Articles

Genetic Polymorphism of Six Transmembrance Protein of Prostate 2 Associated with Diabetes Mellitus in Xinjiang Uygur Population

HAN Rui-mei1, LI Nan-fang2, YAN Zhi-tao2, GUO Yan-ying2, ZHANG Ju-hong2,WANG Hong-mei2, HONG Jing2, ZHOU Ling2   

  1. 1Graduate School of Xinjiang Medical University, Urumqi 830054, China2Center of Hypertension of the Peoples Hospital of Xinjiang Uygur Autonomous Region, Center of Diagnosis,Treatment and Research of Hypertension in Xinjiang, Urumqi 830000, China
  • Received:2012-05-23 Revised:2012-11-07 Online:2012-10-31 Published:2012-10-31
  • Supported by:

    Supported by the National Natural Sciences Foundation of China (30850006)

Abstract:

Objective To investigate the association between the genetic variations of six transmembrance protein of prostate 2 (STAMP2) with type 2 diabetes mellitus (T2DM) in Xinjiang Uygur population. Methods A case-control study was conducted based on epidemiological investigation. A total of 1838 Uygur subjects were selected and divided into two groups: T2DM group (n=274) and control group (n=1564). All exons, flanking introns, and the promoter regions of STAMP2 gene were sequenced in 48 Uygur Xinjiang population with diabetes. Representative variations selected were genotyped by TaqMan-PCR method in all individuals. Results Ten noval and 6 known variations in the STAMP2 gene were identified. The distribution of genotype rs8122 significantly differed between T2DM group and control group (P=0.05), whereas the distribution of genotypes rs1981529 and rs34741656 showed no such difference. The fasting insulin in the total cohort and homeostasis model of assessment index in females showed significant difference between these two groups (P<0.05), while the adjusted P value showed no statistical significance (P>0.05). In the male population, the different genotypes of rs8122 variation of STAMP2 gene were not significantly different (P>0.05). Conclusion Three polymorphisms (rs8122, rs1981529 and rs34741656) of STAMP2 gene may be not related with T2DM in Xinjiang Uygur population.

Key words: six transmembrance protein of prostate 2, genetic polymorphism, Uygur, type 2 diabetes mellitus

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