Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2012, Vol. 34 ›› Issue (6): 590-594.doi: 10.3881/j.issn.1000-503X.2012.06.010

• Original Articles • Previous Articles     Next Articles

Expressions of Clinical Significances of P-Extracellular Regulated Kinase 1/2 and Matrix Metalloproteinase-9 in Cervical Squamous Cell Carcinoma

AN Feng-xian1, WANG Xiao2, LIU Wen3, GAO Yan-li1, MA Jin-long1,3,XU Xing-xin1, CHEN Shi-ming4, YANG Min4   

  1. 1Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan 250012, China;
    2Department of Pathology, School of Medicine, Shandong University, Jinan 250012, China;
    3Shandong Provincial Key Laboratory of Reproductive Medicine, Center for Reproductive Medicine,Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    4Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2011-12-07 Online:2012-12-30 Published:2012-12-30
  • About author:MA Jin-long Tel:0531-85651166,E-mail:majinlong123@hotmail.com

Abstract:

Objective To study the expressions and clinical significances of p-extracellular regulated kinase(P-ERK)1/2 and matrix metalloproteinase-9(MMP-9)in cervical squamous cell carcinoma. Methods The expressions of P-ERK1/2 and MMP-9 in 30 cases with chronic cervicitis, 45 cases with cervical intraepithelial neoplasia (CIN), and 58 cases with cervical squamous cell carcinoma were detected by immunohistochemical method. Results The positive rates of P-ERK1/2 and MMP-9 in chronic cervicitis, CIN, and cervical squamous cell carcinoma were 0 and 0, 28.9% and 24.4%, 77.6% and 65.5%, respectively, showing significant differences among these three groups (χ2= 54.393,p=0.003;χ2=40.968,p=0.005). The positive rates of P-ERK1/2 and MMP-9 in patients at clinical stages Ⅱ - Ⅲ, at G3, with lymphatic metastasis, or with a tumor diameter greater than 4 cm were significantly higher than those at clinical stage Ⅰ(p=0.015,p=0.002), at G1 - G2(p=0.013,p=0.017), without lymphatic metastasis (p=0.017,p=0.021), or with a tumor diameter less or equal than 4 cm in cervical squamous cell carcinoma(p=0.008,p=0.004). There was a positive correlation between P-ERK1/2 and MMP-9 in cervical squamous cell carcinoma (χ2=8.955,p=0.006). Conclusions The expressions of P-ERK1/2 and MMP-9 increase gradually with the progression of cervical squamous cell carcinoma. The overexpressions of P-ERK1/2 and MMP-9 may promote the infiltration of cervical squamous cell carcinoma and lymphatic metastasis, druing which these two enzymes may exert their effets in a synergistic manner.

Key words: p-extracellular regulated kinase 1/2, matrix metalloproteinase-9, cervical squamous cell carcinoma

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