Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2013, Vol. 35 ›› Issue (1): 52-57.doi: 10.3881/j.issn.1000-503X.2013.01.010

• Original Articles • Previous Articles     Next Articles

Association of MK2 Gene Polymorphisms with Low-density LipoproteinCholesterol and Tumor Necrosis Factor-alpha in UygurPopulation from Hetian Area of Xinjiang

LIN Na, LI Nan-fang, YAO Xiao-guang, WANG Hong-mei, LIANG Deng-pan, GUO Yan-ying, ZHOU Ling   

  1. Hypertension center of Peoples Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumqi 830001, China
  • Received:2012-01-31 Online:2013-03-07 Published:2013-03-07
  • Supported by:
    Supported by the High-tech and Development Programs of Xinjiang (201010107)

Abstract: Objective To investigate the association of MK2 gene with low density lipoprotein cholesterol (LDL-C) and tumor necrosis factor-alpha (TNF-α) between different gender in Xinjiang Uygur population. Methods A total of 350 Uygur males and 595 females were recruited randomly from Hetian area. Two single nucleotide polymorphisms (44890c/t, rs 45514798) in MK2 gene were selected and genotyped by Taqman-PCR in these subjects. All subjects underwent questionnaire-based survey, physical examination, measurement of lipid profiles and plasma TNF-α determination. Results Among the male subjects, the concentration of total cholesterol (TC) [TT vs. CT vs. CC: (4.35±1.20) mmol/L vs. (4.69±1.34) mmol/L vs. (4.83±1.44) mmol/L, P=0.033]and TNF-α [TT vs.CT vs.CC: (106.63±62.39) ng/dL vs. (128.44±86.15) ng/dL vs. (153.06±82.99) ng/dL, P=0.001]were significantly different in 3 genotypes of 44890c/t. However, the LDL-C levels in TT, CT, and CC genotypes of 44890c/t were not different neither in males nor in females [males: (2.64±1.16) mmol/L vs. (2.81±1.28) mmol/L vs. (3.04±1.32) mmol/L, P>0.05; females: (2.42±1.11) mmol/L vs. (2.36±0.99) mmol/L vs. (2.43±1.05) mmol/L, P>0.05]. None of the allele and genotype frequencies of 44890c/tand rs 45514798 were different between high LDL-C group and control group. Linear regression analysis indicated that body mass index (BMI) (beta=0.089) and TNF-α (beta=0.092) were significantly associated with LDL-C levels in males (P<0.05), while the age, BMI, and waist/hip ratio with LDL-C levels in females (P<0.05). Conclusion The nucleotide polymorphisms (44890c/t and rs 45514798) in MK2 gene may not be associated with LDL-C in both males and females in the Uygur population in Hetian, Xinjiang.

Key words: MK2 gene, genetic polymorphism, Uygur, gender, low density lipoprotein cholesterol

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