Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2013, Vol. 35 ›› Issue (2): 166-170.doi: 10.3881/j.issn.1000-503X.2013.02.008

• Original Articles • Previous Articles     Next Articles

Efficacy of Iodine-131 in Treating Hyperthyroid Heart Disease

SONG Juan-juan, LIN Yan-song, ZHU Li, LI Fang   

  1. Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2012-04-16 Online:2013-05-03 Published:2013-05-03
  • Contact: LIN Yan-song Tel:010-69155610,


Objective To investigate the value of iodine-131 therapy for hyperthyroidism complicated hyperthyroid heart disease(HHD) induced by Graves’ disease or Plummer disease. Methods Totally 40 HHD cases who were confirmed in our department from 2009 to 2010 were enrolled in this study. All patients received serum thyroid hormones and asscioated antibodies tests, 12-lead electrocardiogram, and/or thyroid imaging before and after iodine-131 therapy to access the treatment effectiveness. Results Among 31 patients with HHD due to Graves’ disease and 9 due to Plummer disease, iodine-131 treatment resulted in euthyroidism in 15 and 5 patients and hypothyroid in 7 and 2 patients, while 9 and 2 remain hyperthyroid, respectively.Serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were statistically significant(P<0.05) before and after iodine-131 therapy, while no significant difference for serum thyrotrophin receptor antibody, antithyroid peroxidase autoantibody, and anti-thyroglobulin antibody.Atrial fibrillation was the most common cardiac complication of hyperthyroidism(n=25, 62.5%) .The remission rate after iodine-131 treatment was 76.0%.Conclusion Iodine-131 therapy can effectively and timely control hyperthyroid in HHD patients.

Key words: iodine-131, hyperthyroidism, hyperthyroid heart disease, atrial fibrillation