Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2013, Vol. 35 ›› Issue (3): 353-356.doi: 10.3881/j.issn.1000-503X.2013.03.021

• Orignal Article • Previous Articles     Next Articles

Effect of Alpha-lipoic Acid Combined with Transient Intensive Insulin Therapy on Adipokine Level in Patients with Type 2 Diabetic Perineuropathy

YANG Lu, ZANG Shu-fei, SONG Mei-qing   

  1. Department of Endocrinology ,Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015,China
  • Received:2013-03-04 Online:2013-07-04 Published:2013-07-04
  • Contact: YANG Lu Tel:0571-88303422,E-mail:


Objective To evaluate the effect of alpha-lipoic acid (LA) combined with transient intensive insulin therapy on adipokine level in patients with type 2 diabetic perineuropathy (DPN). Methods Totally 120 type 2 DPN patients who were receiving transient intensive insulin treatment were equally and randomly divided into LA group and methycobal group (which was set as the control group). The treatment lasted two weeks. The levels of biochemical indicators and adipokine were measured before treament and two weeks after treament. Results After treatment with insulin, serum blood-fasting glucose(FBG), tumor necrosis factor-α(TNFα), and hypersensitive C-reactive protein (HSCRP)were significantly decreased in both LA group and methycobal group(all P <0.05), while adiponectin (APN) significantly increased (both P <0.05). Compared with the methycobal group,the level of APN was significantly higher and those of TNFα and HSCRP were significantly lower in LA group(all P <0.05).Leptin showed no significant change before and after treatment(all P >0.05). Conclusion Transient intensive insulin therapy with LA treatment can regulate adpokine and enhance the anti-inflammatory effect of insulin in type 2 DPN patients.

Key words: type 2 diabetes, alpha-lipoic acid, transient intensive insulin therapy, adipokine