Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2013, Vol. 35 ›› Issue (4): 382-385.doi: 10.3881/j.issn.1000-503X.2013.04.005

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Research Advances in Molecular Pathogenesis of Thyroid Cancer

Aleha·Maotihan,MENG Qing-bin,YU Jian-chun,KANG Wei-ming,CAO Zhan-jiang,TIAN Shu-bo   

  1. Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2013-07-03 Online:2013-08-30 Published:2013-08-30
  • Contact: YU Jian-chun Tel:01069152213,
  • Supported by:
    Supported by the Ministry of Health Industry Special Scientific Research Project(201202012)

Abstract: Thyroid cancer is the one of the most common endocrine tumors.The biological behaviors and prognoses of the thyroid cancer of different histological types remarkably differ.The highly invasive thyroid cancer responds poorly to traditional therapies.Recent research advances in the molecular mechanisms of the pathogenesis of thyroid cancer have revealed the roles of many genetic and epigenetic variations such as gene mutation,abnormal gene amplification,and abnormal gene methylation in the development of thyroid cancer,which provides new insights in the molecular diagnosis,prognosis,and target therapy of the thyroid cancer.

Key words: thyroid cancer, molecular mechanism, molecular target treatment