Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (1): 42-46.doi: 10.3881/j.issn.1000-503X.2014.01.008

• Original Articles • Previous Articles     Next Articles

Correlations between Cellular Immunity and Invasiveness in Differentiated Thyroid Cancer

HAN Ting1, LIANG Jun1, MENG Chao1, YANG Ke2, LI Xiao-yi3, LIN Yan-song4   

  1. 1Department of Oncology, the Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao, Shandong 266003, China
    2Department of Pathology, 3Department of General Surgery, 4Department of Nuclear Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
  • Received:2013-06-27 Online:2014-02-28 Published:2014-02-28
  • Contact: LIN Yan-song Tel:010-69155610,E-mail:linys@pumch.cn E-mail:linys@pumch.cn
  • Supported by:
    Supported by the Ministry of Health Industry Special Scientific Research Projects(201202012)

Abstract: Objective To investigate the relationship between the immunity and invasiveness in differentiated thyroid cancer(DTC).Methods Totally 74 DTC who were treated in Peking Union Medical College Hospital from September 2012 to December 2012 were enrolled in this study.These 74 patients were divided into membrane invasion group(n=36)and without membrane invasion group(n=38);also,they were divided into distant metastasis group(n=18)and without distant metastasis group(n=56).Natural killer(NK)cells and T-cell subsets were chosen as indicators for cellular immunity to investigate the correlation between cellular immunity and invasiveness in DTC.Results Univariate analysis showed that the membrane invasion(χ2=12.175,P=0.000)and distant metastasis(χ2=8.139,P=0.006)correlated with cell immunity,whereas distant metastasis correlated with lymphocytic thyroiditis(χ2=7.094,P=0.008).Further investigation shows that distant metastasis was associated with the percentage of CD8+T cell subgroup(χ2=5.429,P=0.020),and membrane invasion was significantly associated with NK cells(χ2=2.445,P=0.018)and CD4/CD8 disorder subgroup(χ2=8.079,P=0.002).Multivariate analysis showed that cell immunity disorder was a risk factor for membrane invasion[OR=5.701,95%CI(2.075~15.666),P=0.001]and distant metastasis[OR=5.063,95%CI (1.571~16.320),P=0.008].Further analysis showed that CD8+T cell was a risk factor for metastasis[OR=2.236,95%CI( 1.084~4.613),P=0.029],and CD4/CD8 disorders were the risk factors for membrane invasion[OR=2.802,95%CI(1.257~6.244),P=0.012].Conclusion Cell immunity in thyroid cancer has close relationship with membrane invasion and distant metastasis,especially when the percentage of CD8+T cells decreases and when the NK cells and CD4/CD8 are abnormal,which may lead to membrane invasion and distant metastasis.

Key words: differentiated thyroid cancer, distant metastasis, regional invasiveness, cellular immune system

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