Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (1): 86-91.doi: 10.3881/j.issn.1000-503X.2014.01.016

• Original Articles • Previous Articles     Next Articles

Quantitative T2 Mapping Evaluates the Repaired Articular Cartilage

CHEN Min1, XU Xian1, HAN Shao-jun1, TANG Yan-hua1, ZHANG Jun1, DONG Tian-ming1, ZUO Pan-li2, AN Ning-yu1   

  1. 1 Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China
    2 Division of Magnetic Resonance Imaging, Healthcare Business, Siemens Ltd.China, Beijing 100102, China
  • Received:2013-08-23 Online:2014-02-28 Published:2014-02-28
  • Contact: AN Ning-yu Tel:010-66876358,


Objective To evaluate the value of T2 mapping in monitoring the repaired cartilage after matrix-associated autologous chondrocyte implantation/transplantation(MACI/MACT).Methods Four patients(10 plug cartilages)were examined three times by T2 mapping at 1,3,and 6 months using a 3.0 Tesla MR scan system.Quantitative mean(full-thickness)T2 values were calculated in the transplanted area and control cartilage.Paired t-tests were used to compare the T2 values between transplanted and control cartilage.For analysis of longitudinal T2 values,one-way analyses of variance were performed among 1,3,and 6 months after MACI.Results The mean T2 values of the transplanted area at 1,3,and 6 months after MACI were(82.40±15.23),(71.09±13.06),(53.80±4.86)ms,respectively.There were significant differences between the transplanted and control cartilage at 1 and 3 months(both P<0.01)after MACI,but not at 6 months(P=0.196).There were significant differences among T2 values of 1,3,and 6 months after MACI in transplanted area(P=0.03).Conclusion T2 mapping provides a useful tool for monitoring the biochemical development of the transplanted cartilage and can be used to evaluate the cartilage repair noninvasively.

Key words: T2 value, cartilage, knee, matrix-induced autologous chondrocyte implantation/transplantation

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