microRNA在气道变应性疾病中的研究进展

doi:10.3881/j.issn.1000-503X.2014.01.021

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (1): 114-118.doi: 10.3881/j.issn.1000-503X.2014.01.021

• Review • Previous Articles

Roles of microRNAs in Allergic Airway Diseases

TENG Yao-shu, CAO Xiao-lin, LI Yong

Department of Otorhinolaryngology, Hangzhou First People’s Hospital, Hangzhou 310006, China

Received:2013-10-14 Online:2014-02-28 Published:2014-02-28
Contact: LI Yong Tel:0571-56008888,E-mail:Leeyung828@hotmail.com E-mail:Leeyung828@hotmail.com
Supported by:
Supported by the Backbone Talents Project from Health Bureau of Zhejiang Province(2013RCA041)

Abstract

Abstract: The microRNAs(miRNAs/miRs)are a class of short non-coding RNAs regulating protein translation via mRNAs silencing.Studies have shown that microRNAs play critical roles in allergic diseases,tumors,and infections.The allergic airway diseases are characterized by inflammation and hyperresponsiveness of the respiratory tract.Several miRNAs are found to be involved in a series of pathophysiologic processes in allergic airway diseases including inflammatory cells infiltration,cytokines’ expressions,airway hyperresponsiveness,and proliferation and change in phenotype of smooth muscle cells.Therefore,miRNAs may be new therapeutic targets for these allgeric diseases.This article reviews the roles of miRNAs in asthma and allergic rhinitis and their molecular biological mechanisms.

Key words: microRNA, asthma, allergic rhinitis, airway inflammation

CLC Number:

R392.8

TENG Yao-shu, CAO Xiao-lin, LI Yong. Roles of microRNAs in Allergic Airway Diseases[J].Acta Academiae Medicinae Sinica, 2014, 36(1): 114-118.

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