Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (3): 309-312.doi: 10.3881/j.issn.1000-503X.2014.03.015

• Original Articles • Previous Articles     Next Articles

Effect of Piglitazone and Metformin on Retinol-binding Protein-4 and Adiponcetin in Patients with Type 2 Diabetes Mellitus Complicated with Non-alcohol Fatty Acid Liver Diseases

YANG Lu,SONG Mei-qing,ZHANG Qiu-ling,SHOU Lan,ZANG Shu-fei,YANG Yan-li   

  1. Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal University,Hangzhou 310015,China
  • Received:2013-09-17 Online:2014-06-28 Published:2014-06-28
  • Contact: YANG Lu Tel:0571-88358082,E-mail:ida2013@aliyun.com

Abstract:

Objective To compare the effects of piglitazone and metformin on retinol-binding protein-4(RBP-4)and adiponcetin(APN)in patients with type 2 diabetes mellitus(T2DM)complicated with Non alcohol fatty acid liver disease(NAFLD). Methods Totally 60 T2DM patients complicated with NAFLD were equally and randomly divided into pioglitazone group and metform group. The levels of biochemical indicators including body mass index(BMI),glucose hemoglobin A1C(GHbA1C),insulin resistance(HOMA-IR),fasting blood glucose(FBG),fasting insulin(FIns),and serum triglycerides(TG)as well as serum RBP-4 and APN level were measured pre-treatment and 12 weeks after treatments. Results After 12 weeks of treaments,BMI,FBG,HOMA-IR,GHbA1C,FIns,and TG decreased(all P<0.05)in both piglitazone group and metform group. APN increased(all P<0.05)in both groups. RBP-4 decreased(P<0.05)in piglitazone group. Compare with the metform group,the levels of RBP-4,FIns,and HOMA-IR decreased and BMI increased in piglitazone group(P<0.05). Conclusion Piglitazone is superior to metoform in decreasing RBP-4 level and HOMA-IR in patients with T2DM complicated with NAFLD.

Key words: type 2 diabetes mellitus, non-alcohol fatty acid liver diseases, piglitazone, metformin, retinol binding protein-4, adiponcetin

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