Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (3): 313-316.doi: 10.3881/j.issn.1000-503X.2014.03.016

• Original Articles • Previous Articles     Next Articles

Therapeutic Effect of Inulin on Enteric Hyperoxaluria in Rats

TIAN Jing1,PENG Jie2,GE Wei-hong2,ZHANG Jun1   

  1. 1Emergency Center,2Department of Clinical Pharmacy,the Affiliated Drum Tower Hospital of Nanjing University,Nanjing 210008,China
  • Received:2013-03-27 Online:2014-06-28 Published:2014-06-28
  • Contact: TIAN Jing Tel:025-83304616-60115,E-mail:tianjing8372@sina.com

Abstract:

Objective To observe the therapeutic effect of inulin on enteric hyperoxaluria in rats. Methods In experimental A,24 healthy male Sprague-Dawley rats received an oxalate-free diet on day 1,a high-oxalate diet(oxalate,74.82 mg/100 g feed stuffs)on days 2 and 3,and plus 2 g inulin to each rat on day 3. The 24-hour urinary volume,concentrations of urinary oxalate and urine creatinine were measured,and 24-hour urinary oxalate excretion was calculated. In experimental B,24 healthy male Sprague-Dawley rats were equally randomized into control group and inulin group,Each rat received a high oxalate diet(oxalate,74.82 mg/100 g feedstuffs),and plus 2 g inulin in inulin group. The 24-hour urinary oxalate excretion was calculated in both two groups. Results In experimental A,the 24-hour urinary oxalate excretion varied with time(F=11.481,P=0.035). The 24-hour urinary oxalate excretion significantly increased on day 2 compared with that on day 1(P=0.026)and day 3(P=0.037);it significantly increased on day 3 compared with day 1(P=0.004). In experimental B,the 24-hour urinary oxalate excretion significantly decreased in inulin group compared with the control(P=0.011). Conclusion Inulin may have potential therapeutic effect on enteric hyperoxaluria in rats.

Key words: inulin, prebiotics, probiotics, hyperoxaluria, calcium oxalate calculus

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