Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (4): 357-362.doi: 10.3881/j.issn.1000-503X.2014.04.003

• Original article • Previous Articles     Next Articles

Study of Animal Model of Osteonecrosis Induced by Local Ethanol Injection in Emu

FAN Meng1,2,JIANG Wen-xue1,WANG Ai-yuan2,PENG Jiang2,ZHANG Li2,XU Wen-jing2,LU Shi-bi2   

  1. 1Department of Orthopeadics,Tianjin First Central Hospital,Tianjin 300192,China; 2Institute of Orthopeadics,Chinese PLA General Hospital,Beijing 100853,China
  • Received:2013-12-31 Online:2014-08-31 Published:2014-08-31
  • Contact: PENG Jiang Tel:010-66939202,
  • Supported by:
    Supported by the Science & Technology Star of Beijing(Z121107002512072)

Abstract: Objective To establish a new animal model of osteonecrosis of the femoral head by local ethanol injection in emu. Methods Eight milliliter ethanol was injected slowly to the operated femoral head with customized probe in twenty adult male emus. Postoperatively,hip magnetic resonance imaging was performed at 1,4,8,12 weeks. After emus were sacrificed,the femurs were collected for micro-computed tomography and histological analysis. Results No emu demonstrated signs of infection or died unexpectedly. Magnetic resonance imaging examination showed broad edema at proximal femur at 1th week,and the edema decreased with time,till local edema at femoral head at the 12th week. Histological images showed human-like osteonecrotic changes with active bone repair. There were significant differences in trabecular structure and bone mineral density bet-ween the operated and intact femoral heads. No collapse was found 6 months after the operation. Conclusions This emu model of femoral head osteonecrosis by local ethanol injection can progress to early stage osteonecrosis. The different repair methods may have certain correlation with the results of osteonecrosis of the femoral heads.

Key words: osteonecrosis of the femoral head, animal model, ethanol, emu

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