Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (4): 369-376.doi: 10.3881/j.issn.1000-503X.2014.04.005

• Original article • Previous Articles     Next Articles

Effects of Apolipoprotein A1 Gene rs670 and rs5069 Polymorphisms on the Plasma Lipid Profiles in Healthy Adolescents with Different Body Mass Index

SONG Yong-yan1,2,GONG Ren-rong1,ZHANG Zhen1,LI Yuan-hao1,FAN Mei1,OU Guo-jin1,FANG Ding-zhi1   

  1. 1Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China;2Department of Biochemistry,School of Preclinical Medicine,North Sichuan Medical College,Nanchong,Sichuan 637007,China
  • Received:2014-02-12 Online:2014-08-31 Published:2014-08-31
  • Contact: FANG Ding-zhi Tel:028-85471567,
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81171319) and Nursery Fund of PLA General Hospital(13KMM41)

Abstract: Objective To investigate the possible effects of apolipoprotein A1 gene (APOA1) rs670 and rs5069 polymorphisms on plasma lipid profiles in healthy adolescents with different body mass index (BMI). Methods Totally 723 adolescents were divided into four groups according to their BMI:group 1[BMI=(17.80±0.75)kg/m2],group 2[BMI=(19.39±0.32) kg/m2],group 3[BMI=(20.68±0.43) kg/m2],and group 4[BMI=(23.40±2.05) kg/m2]. Height,weight,waist circumference,hip circumference,blood pressure,heart rate,plasma lipids,and blood glucose were determined,BMI and waist to hip ratio (W/H ratio) were calculated,and genome DNA was extracted for analyzing the genotypes of the APOA1 rs670 and rs5069 polymorphisms by polymerase chain reaction-restriction fragment length polymorphism. Results No significant differences in height,weight,BMI,waist circumference,hip circumference,W/H ratio,blood pressure,heart rate,plasma lipids,and blood glucose between APOA1 rs670 or rs5069 genotypes were observed among group 1,group 2,and group 3. In group 4,A carriers of the rs670 polymorphism had significantly higher systolic blood pressure (P=0.017) and blood glucose levels (P=0.009) than the adolescents with the GG genotype. T carriers of the rs5069 polymorphism had significantly higher height (P=0.013),weight (P=0.011),and hip circumference (P=0.026) than the adolescents with the CC genotype. Conclusions In healthy adolescents with higher BMI,APOA1 rs670 polymorphism is associated with systolic blood pressure and blood glucose levels. The elevation of systolic blood pressure and blood glucose levels in A carriers of APOA1 rs670 polymorphism may be favorably modulated by weight loss.

Key words: apolipoprotein A1 gene, body mass index, lipid, polymorphism

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