Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (4): 432-438.doi: 10.3881/j.issn.1000-503X.2014.04.015

• Original article • Previous Articles     Next Articles

A Voxel-based Morphometry Study of Grey Matter Volume Changes in Neuromyelitis Optica Patients

CHEN Cong1,HOU Bo1,YOU Hui1,LV Yue-lei1,XU Yan2,FENG Feng1   

  1. 1Department of Radiology,2Department of Neurology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2014-02-28 Online:2014-08-31 Published:2014-08-31
  • Contact: FENG Feng Tel:010-69155480,E-mail:cjr.fengfeng@vip.163.com
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81070401),and Health Nonprofit Industry Research and Special Project Fund (201202017)

Abstract: Objective To explore the grey matter volume(GMV)changes in neuromyelitis optica(NMO)patients using a voxel-based morphometry method. Methods Whole brain structural images were acquired in 16 NMO patients and 16 gender-and age-matched healthy controls. Comparison of GMV between the two groups was analyzed by VBM8 toolbox of statistical parametric mapping 8. Result Compared with the controls,NMO patients showed decreased GMV in the frontal lobe,parietal lobe,temporal lobe,occipital lobe,limbic lobe,optic tract,caudate nucleus,thalamus,and cerebellum(all P<0.005). Conclusions Regional atrophy of grey matter is found in NMO patients. Voxel-based morphometry can reveal brain volume changes sensitively.

Key words: neuromyelitis optica, magnetic resonance imaging, voxel-based morphometry, grey matter

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