Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (4): 450-453.doi: 10.3881/j.issn.1000-503X.2014.04.018

• Review • Previous Articles     Next Articles

Prognostic Factors and Associated Models for Metastatic Renal Cell Carcinoma Treated with Targeted Therapy

ZHENG Ke-wen,LI Han-zhong,LI Yong-qiang   

  1. Department of Urology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2014-02-24 Online:2014-08-31 Published:2014-08-31
  • Contact: LI Han-zhong Tel:010-69156035,E-mail:lihanzhong_ pumc@163.com
  • Supported by:
    Supported by the National Natural Sciences Foundation of China (81171262,81371473),and the Fundamental Research Funds for the Central Universities(2011JDHZ59)

Abstract: Since 2006,tyrosine kinase inhibitors and anti-angiogenic drugs have revolutionized the treatment of metastatic renal cell carcinoma by improving progression-free survival and overall survival. The prognostic factors in metastatic renal cell carcinoma treated by targeted therapy include anatomical,histological,clinical,biological,and molecular parameters. The accuracy of these prognostic factors are not high when applied alone. A renal cancer prognostic system that combines all these prognostic factors can improve the risk assessment of renal cancer and prognosis prediction,and thus guide clinical decision-making.

Key words: metastases, renal cell carcinoma, targeted therapy, prognostic factors, models

CLC Number: