Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2014, Vol. 36 ›› Issue (4): 454-460.doi: 10.3881/j.issn.1000-503X.2014.04.019

• Review • Previous Articles    

Histidine Triad Nucleotide-binding Protein 1 and Human Diseases

DANG Yong-hui1,LIU Zhong-wei2,CHEN Feng3,GUO Kun4,WANG Jia-bei5   

  1. 1College of Medicine & Forensics,Xi’an Jiaotong University Health Science Center,Key Laboratory of the Health Ministry for Forensic Medicine,Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry,Xi’an 710061,China; 2Department of Cardiology,Shanxi Provincial People’s Hospital,Xi’an 710061,China;3Department of Forensic Medicine,Nanjing Medical University,Nanjing 210029,China; 4Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi’an Jiaotong University Health Science Center,Xi’an 710061,China;5Department of Pharmaceutical Sciences,School of Pharmacy,University of Maryland Baltiore,Baltiore MD 21201,USA
  • Received:2014-02-12 Online:2014-08-31 Published:2014-08-31
  • Contact: DANG Yong-hui Tel:029-82655237,E-mail:psydyh@mail.xjtu.edu.cn

Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx,in which x represents hydrophobic amino acid. HINT1 is implicated in pathological progress of many human diseases including cancer and schizophrenia;however,little is known about the essential role and pathological consequences of HINT1 in cellular physiology and diseases. Therefore,we summarize the structure,distribution,and physiological function of HINT1 in cells and tissues as well as the correlation between HINT1 and human diseases.

Key words: histidine triad nucleotide-binding protein 1, cancer, neuropsychiatric diseases, type 2 diabetes, hepatic ischemic/reperfusion, liver fibrosis

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