Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (1): 108-112.doi: 10.3881/j.issn.1000-503X.2015.01.020

• Orginal Article • Previous Articles     Next Articles

Bone Marrow-derived Mesenchymal Stem Cells in the Treatment of Myocardial Infarction

Jin-feng LIU, Bin LING()   

  1. Department of Intensive Care Unit,the 4th Affiliated Hospital,Kunming Medical University,Kunming 650051,China
  • Received:2014-08-13 Online:2015-02-28 Published:2015-02-12
  • Supported by:
    Supported by the National Nature Sciences Foundation of China(81360289)and the Basic Research for Application Plan Project of Yunnan(40212060)

Abstract:

Bone marrow-derived mesenchymal stem cells(BMSCs)have the ability to regenerate myocadial tissue. BMSCs transplantation can produce cardiac-like cells,promote angiogenesis,and secrete a variety of growth factors and cytokines. This article summarizes the molecular mechanisms of myocardial repair,explores the potential regenerative capacity of cardiac muscles after myocardial infarction,and reviews the previous studies on BMSC transplantation for treatment of cardiac muscle after myocardial infarction,with an attempt to provide new insights in clinical decision-making.

Key words: bone marrow-derived mesenchymal stem cells, myocardial infarction, stem cell transplantation

CLC Number: