Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (2): 171-178.doi: 10.3881/j.issn.1000-503X.2015.02.007

• Orginal Article • Previous Articles     Next Articles

Application of Plasma Clearance of Iohexol in Evaluating Renal Function in Chinese Children with Chronic Kidney Disease

Bao-bao WANG1, Yuan WU1, Yan QIN1, Meng-chun GONG1, Xi-min SHI2, Hong-li JING2, Fang LI2, Chao-ying CHEN3, Hong-mei SONG4, Xue-mei LI1()   

  1. 1Department of Nephrology,
    2Department of Nuclear Medicine,
    4Department of Pediatrics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    3Children’s Hospital Affiliated to Capital Institute of Pediatrics,Being 100020,China
  • Received:2014-08-25 Online:2015-02-28 Published:2015-05-01
  • Supported by:
    Supported by the Beijing Municipal Science and Technology Commision(D131100004713007,D09050704310901)

Abstract: ObjectiveTo evaluate the accuracy of plasma clearance of iohexol(PCio)for glomerular filtration rate(GFR)measurement in Chinese children with chronic kidney disease(CKD)and assess the feasibility of single-blood-sample method or dried capillary blood spots in determining the PCio.MethodsTotally 45 CKD children were included,in whom the 99mTechnetium-diethylenetriaminepentaacetic acid(99mTc-DTPA)plasma clearance and iohexol plasma clearance were simultaneously determined.Blood samples were obtained 2,4,and 5 hours after injection.In addition,we also evaluated the efficacy of single blood sample method and dried blood spots method in iohexol plasma clearance.ResultsForty-five CKD children completed the iohexol plasma clearance and thirty-six children completed the 99mTc-DTPA plasma clearance at the same time among them.Thirteen children finished the iohexol dried blood spot clearance.The correlation coefficient between 99mTc-DTPA plasma clearance and iohexol plasma clearance was 0.941 and the bias was(6.53±11.6)ml/(min·1.73 m2),and the intraclass correlation coefficient(ICC)was high(ICC=0.947).The correlation between iohexol single-sample plasma clearance and double samples was also strong(r=0.958),with the bias being(4.26±9.06)ml/(min·1.73 m2)and the ICC being 0.970.The iohexol clearance by dried blood spots showed a good correlation with the serum iohexol clearance(r=0.950),with the bias still being small [(0.48±10.89)ml/(min·1.73 m2)].ConclusionsIohexol plasma clearance has satisfactory agreement with 99mTc-DTPA plasma clearance and can be used as an ideal method to measure GFR in CKD children.The single-sample method and dried blood spots method make iohexol plasma clearance more convenient and practical.

Key words: iohexol plasma clearance, children, chronic kidney disease, glomerular filtration rate

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