Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (2): 221-225.doi: 10.3881/j.issn.1000-503X.2015.02.014

• Orginal Article • Previous Articles     Next Articles

Values of Iodine Metabolism Biomarkers in Assessing the Iodine Nutrition Status in Surgically Treated Patients with Thyroid Disease

Jian-hua HAN1, Lian WU2, Song-lin YU1, Hui-ling FANG1, Wei-ming KAMG2, Xin-qi CHENG1, Jie LU1, Jian-chun YU2(), Ling QIU1()   

  1. 1Department of Clinical Laboratory,
    2Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2014-08-25 Online:2015-02-28 Published:2015-05-01
  • Supported by:
    Supported by the Ministry of Health Industry Special Scientific Research Project(201202012)

Abstract: ObjectiveTo assess the clinical application value of iodine metabolism biomarkers in assessing iodine nutrition status in surgically treated patients with thyroid disease.MethodsBlood,morning urine and 24-hour urine samples were collected in 31 healthy volunteers and in 30 surgically treated patients with thyroid disease before and after surgery.Iodine concentration was analyzed by inductively coupled plasma mass spectrometry.The iodine metabolism biomarkers including serum iodine(SI),morning urine iodine(UI),morning urine iodine/urine creatinine ratio(UI/UCr),24-hour urine iodine(24 h UI),and 24-hour urine iodine excretion(24 h UIE)were evaluated in these two groups.In addition,the validation coincidence rate of iodine metabolism biomarkers in healthy volunteers to different reference ranges including World Health Organization,Mayo Clinic,and Quest Diagnostics were calculated.ResultsThe UI/UCr ratio of pre-operative thyroid disease patients was significantly lower than that of healthy volunteers(P<0.05),while the other biomarkers showed no significant differences(all P>0.05)between these two groups.The SI,UI,and 24 h UI in postoperative thyroid disease patients were significantly higher than those of the pre-operative patients(all P<0.05).Though the medians of all biomarkers in healthy volunteers were within the reference ranges,only the validation coincidence rates of SI,UI,and UI/UCr in the 41-70-year populations were over than 90% according to Mayo Clinic;furthermore,the area under the receiver operating characteristic curve about UI/UCr ratio(0.737)was the biggest within the iodine metabolism biomarkers.ConclusionThe UI/UCr ratio may be used for iodine nutrition evaluation in surgically treated patients with thyroid disease.

Key words: serum iodine, urine iodine, thyroid disease

CLC Number: