Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (2): 246-252.doi: 10.3881/j.issn.1000-503X.2015.02.019

• Orginal Article • Previous Articles    

Advances in the Proinflammatory Effects of Visfatin and Its Relationship with Diabetic Kidney Disease

Liang-yan ZHANG, Xue-mei LI()   

  1. Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2014-11-05 Online:2015-02-28 Published:2015-05-01
  • Supported by:
    Supported by the Beijing Natural Sciences Foundation(7122143)


Visfatin,also known as the pre-B-cell colony enhancing factor,is a new member of the adipocytokines.It serves as a nicotinamide phosphoribosyltransferase in cells.Visfatin has complex biological functions and may be involved in the pathogenesis of diabetic kidney disease;it may contribute to the chronic inflammatory status at systemic and renal levels and thus aggravate renal injury.Further research on visfatin will provide new insights in the treatment of diabetic kidney disease.This article reviews the recent advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.

Key words: visfatin, pre-B-cell colony enhancing factor, nicotinamide phosphoribosyltransferase, diabetic kidney disease

CLC Number: