Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (3): 274-278.doi: 10.3881/j.issn.1000-503X.2015.03.005

• Orginal Article • Previous Articles     Next Articles

Association between KLKB1 Polymorphisms and Pulmonary Thromboembolism

Min-ne WANG1,2, Xiao-mao XU3, Zhen-guo ZHAI4, Liang SUN5, Bao-min FANG3, Fei XIAO5, Jian GUO5()   

  1. 1Graduate School,CAMS and PUMC,Beijing 100730,China
    2National Center for Clinical Laboratories,Beijing Hospital,Beijing 100730,China
    3Department of Respiratory and Critical Care Medicine,Beijing Hospital,Bejing 100730,China
    4Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders,Beijing Institute of Respiratory Medicine,Department of Respiratory Disease,Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020,China
    5Beijing Institute of Geriatric Medicine,Beijing Hospital,Beijing 100730,China
  • Received:2015-02-04 Online:2015-05-23 Published:2015-06-30
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81170050),the Science and Technology Nova Plan of Beijing(z121107002512058),the National Science & Technology Pillar Program during the 12th Five-year Plan Period(2011BAI11B17),and the National Department Public Benefit Research Foundation by Ministry of Health(201302008)

Abstract: Objective

To investigate the potential correlation between the single nucleotide polymorphisms(SNPs)in the KLKB1 region and pulmonary thromboembolism(PTE)in a Chinese Han population.


In this case-control study,95 patients with confirmed PTE were enrolled as the PTE group and 90 healthy subjects as the control group. The genotypes,alleles,and haplotypes of the SNPs were analyzed with PLINK 1.07 and Haploview 4.2 software using chi-square test and Logistic regression analysis. SNPs were further analyzed under three genetic models(additive,dominant,and recessive).


The distribution of rs3733402 in KLKB1 gene showed significant difference between PTE group and control group(P=0.041). The distributions of GTG haplotypes consisted of rs2292423,rs4253325,and rs3733402 in KLKB1 gene were also significantly different between PTE group and control group(P=0.040).


The rs3733402 locus variation in KLKB1 gene is associated with PTE in Chinese Han people.

Key words: single nucleotide polymorphisms, pulmonary thromboembolism, KLKB1, plasma prekallikrein

CLC Number: