Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (3): 320-324.doi: 10.3881/j.issn.1000-503X.2015.03.014

• Orginal Article • Previous Articles     Next Articles

Imaging Potential and Biodistribution in vivo of 2-[18F]Fluoropropionic Acid in Breast Cancer-bearing Mice

Yong-hong DANG, Jiong CAI(), Xin LI, Ling WANG, Fang LI   

  1. Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2015-04-07 Online:2015-05-23 Published:2015-06-30

Abstract: Objective

To investigate the imaging potential and biodistribution in vivo of a novel positron imaging agent,2-[18F]fluoropropionic,in breast cancer-bearing mice.

Methods

2-[18F]fluoropropionic acid (7.4-11.1 MBq)was injected into the breast cancer-bearing mice via tail vein,followed by micro positron emission tomography at 60min and 120min.The radioactivity per volume (Bq/ml) in organs was transferred to percentage injected dose per gram(% ID/g)by Inveon Research software and the biodistribution of 2-[18F]fluoropropionic acid in organs was deduce.The same operations were done with 18F-FDG.

Results

2-[18F]fluoropropionic acid was mainly distributed in the urinary bladder,intestine,and liver between 60 min to 120 min.The breast cancer at right flank was visualized clearly,and the radioactivity uptake was (13.74±1.97)% ID/g and (14.84±1.06)% ID/g,respectively,at these two time points (P=0.454).The radioactivity uptakes in muscle and brown tissue were relatively low.The radioactivity uptake of 18F-FDG was (10.27±2.34)% ID/g at the breast cancer 60 min after injection,and radioactivity uptake of the brown fat on the back was obvious.

Conclusions

Positron imaging agent 2-[18F]fluoropropionic acid can be used to image breast cancer.It may be applied in the noninvasive imaging of breast cancer in clinical settings.

Key words: 2-[18F]fluoropropionic acid, breast cancer-bearing mice, micro positron emission tomography, imaging

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