Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (4): 406-414.doi: 10.3881/j.issn.1000-503X.2015.04.007

• Orginal Article • Previous Articles     Next Articles

Roles of Tumor-infiltrating Lymphocytes in Non-small Cell Lung Cancer Recurrence and Metastasis:A Meta Analysis

Xiang YAN, Shun-chang JIAO()   

  1. Department of Oncology,Chinese PLA General Hospital,Beijing 100853,China
  • Received:2014-09-30 Online:2015-05-25 Published:2015-08-31

Abstract: Objective

To determine the prognostic value of tumor-infiltrating lymphocytes in the recurrence and metastasis of non-small cell lung cancer(NSCLC).


A PubMed,EMBASE,Cochrane Library databases,NIH databases,and China Biology Medicine disc,China National Knowledge Infrastructure,Chinese Science and Technology Periodical literature search strategy was designed. Studies on the prognostic values of intratumoural CD3+,CD4+,CD8+,and FoxP3+lymphocytes for NSLCL were retrieved. RevMan 5.1 was applied for Meta analysis.


Totally 8 studies entered the final analysis. In pooled analysis of 1197 patients,the high expressions of CD3+and CD8+cells were correlated with the increase of overall survival(OS)(OR=0.52,95% CI=0.40-0.68,P<0.0001;OR=0.52,95% CI=0.34-0.79,P=0.002),and the high expression of CD8+was significantly correlated with the increase of disease-free survival(DFS)(OR=0.68,95% CI=0.51-0.91,P=0.01). The CD4+cell expression level was not significantly correlated with OS or DFS(P=0.14,P=0.73). The high expression of FoxP3+cells did not favor the DFS(OR=1.78,95% CI=1.36-2.31;P<0.0001).


The expression levels of CD3+,CD8+and FoxP3+in NSCLC microenviroment are related with the prognosis of NSCLC,while the role of CD4+in the development of NSCLC warrants further investigations.

Key words: non-small cell lung cancer, immune microenvironment, tumor-infiltrating lymphocyte, cytokine, prognosis

CLC Number: