肿瘤浸润淋巴细胞与非小细胞肺癌预后关系的Meta分析

doi:10.3881/j.issn.1000-503X.2015.04.007

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (4): 406-414.doi: 10.3881/j.issn.1000-503X.2015.04.007

• Orginal Article • Previous Articles Next Articles

Roles of Tumor-infiltrating Lymphocytes in Non-small Cell Lung Cancer Recurrence and Metastasis:A Meta Analysis

Xiang YAN, Shun-chang JIAO()

Department of Oncology,Chinese PLA General Hospital,Beijing 100853,China

Received:2014-09-30 Online:2015-05-25 Published:2015-08-31

Abstract

Abstract: Objective

To determine the prognostic value of tumor-infiltrating lymphocytes in the recurrence and metastasis of non-small cell lung cancer(NSCLC).

Methods

A PubMed,EMBASE,Cochrane Library databases,NIH databases,and China Biology Medicine disc,China National Knowledge Infrastructure,Chinese Science and Technology Periodical literature search strategy was designed. Studies on the prognostic values of intratumoural CD3+,CD4+,CD8+,and FoxP3+lymphocytes for NSLCL were retrieved. RevMan 5.1 was applied for Meta analysis.

Results

Totally 8 studies entered the final analysis. In pooled analysis of 1197 patients,the high expressions of CD3+and CD8+cells were correlated with the increase of overall survival(OS)(OR=0.52,95% CI=0.40-0.68,P<0.0001;OR=0.52,95% CI=0.34-0.79,P=0.002),and the high expression of CD8+was significantly correlated with the increase of disease-free survival(DFS)(OR=0.68,95% CI=0.51-0.91,P=0.01). The CD4+cell expression level was not significantly correlated with OS or DFS(P=0.14,P=0.73). The high expression of FoxP3+cells did not favor the DFS(OR=1.78,95% CI=1.36-2.31;P<0.0001).

Conclusion

The expression levels of CD3+,CD8+and FoxP3+in NSCLC microenviroment are related with the prognosis of NSCLC,while the role of CD4+in the development of NSCLC warrants further investigations.

Key words: non-small cell lung cancer, immune microenvironment, tumor-infiltrating lymphocyte, cytokine, prognosis

CLC Number:

R73-31/R734.2

Xiang YAN, Shun-chang JIAO. Roles of Tumor-infiltrating Lymphocytes in Non-small Cell Lung Cancer Recurrence and Metastasis:A Meta Analysis[J].Acta Academiae Medicinae Sinica, 2015, 37(4): 406-414.

Figures/Tables 7

Table 1

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Table 2

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References 32

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文献 Literature	第一作者 1^st author	国家 Location	发表时间 Public date	病例数 NO. of cases	病例分布 Case distribution	研究方法 Experiment method
5	Liu H	中国 China	2012	211	2000-2002	IHC
6	Zhuang X	中国 China	2010	30	1999-2001	IHC
7	Dimitrakopoulos FI	希腊 Greece	2011	67	2005-2008	IHC
8	Wakabayashi O	日本 Japan	2009	198	1976-1994	IHC
9	Ruffini E	意大利 Italy	2009	290	1993-2006	IHC
10	Kawai O	日本 Japan	2008	119	1996-2004	IHC
11	Liu H	中国 China	2012	244	2000-2005	IHC
12	Shimizu K	日本 Japan	2010	382	1999-2005	IHC

因素 Factors	固定效应计算结果 Results of fixed-effects model	随机效应计算结果 Results of random-effects model
CD3-OS	0.53(0.42~0.66)	0.52(0.40~0.68)
CD4-OS	0.75(0.55~1.02)	0.73(0.48~1.11)
CD8-OS	0.52(0.35~0.77)	0.52(0.34~0.79)
Foxp3-OS	1.32(1.01~1.72)	1.33(0.95~1.86)
CD3-DFS	0.94(0.74~1.18)	0.94(0.74~1.18)
CD4-DFS	0.93(0.72~1.21)	0.94(0.66~1.33)
CD8-DFS	0.68(0.51~0.91)	0.68(0.51~0.91)
Foxp3-DFS	1.77(1.36~2.29)	1.78(1.36~2.31)

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