Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (4): 446-450.doi: 10.3881/j.issn.1000-503X.2015.04.014

• Orginal Article • Previous Articles     Next Articles

Morphology of Hypertrophic Scar Tissues and Expressions of Vascular Endothelial Growth Factor and Transforming Growth Factor Beta Activated Kinase 1 in These Tissues

Yu-fei ZHANG1, Hou-zhong LI2, Xue-yong WANG3, Hong-chuang MA1, Yan WU1, Xiao-huan YUAN1, Yan-hui CHU1()   

  1. 1Medical Research Center,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China
    2Department of Pharmacology,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China
    3Department of Burn Surgery,the 209 Hospital of Chinese People’s Liberation Army,Mudanjiang,Heilongjiang 157011,China
  • Received:2015-01-19 Online:2015-05-25 Published:2015-08-31

Abstract: Objective

To observe the morphology of hypertrophic scar tissue and explore the expressions and distribution of vascular endothelial growth factor(VEGF)and transforming growth factor beta activated kinase 1(TAK1)in these tissues.


Hematoxylin-eosin staining,Masson staining,immunofluorescence,and real-time polymerase chain reaction were used to detect the localization and expression of VEGF and TAK1 in 15 hypertrophic scar tissues and 10 normal skin tissues.


Morphological observation showed that the dermal fibroblasts in hypertrophic scar were disorderly and densely arranged(compared to the normal skin). Immunofluorescence displayed that the expressions of VEGF and TAK1 in hypertrophic scar tissue were higher than in normal skin tissues. Real-time polymerase chain reaction showed the mRNA expressions of both VEGF and TAK1 were significantly higher in hypertrophic scar tissue than in normal tissue(P<0.01,P<0.05,respectively).


Hypertrophic scar tissue has higher collagen fibrosis degree and higher TAK1 and VEGF expressions than the normal skin. VEGF and TAK1 can be used as the reference indicators for the diagnosis and differential diagnosis of hypertrophic scar and serve as new therapeutic targets.

Key words: hypertrophic scar, collagen fibrosis, vascular endothelial growth factor, transforming growth factor-beta-activated kinase 1

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