冠心病的基因组学研究现状

doi:10.3881/j.issn.1000-503X.2015.04.019

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (4): 475-481.doi: 10.3881/j.issn.1000-503X.2015.04.019

• Orginal Article • Previous Articles Next Articles

Advances in Genomics Studies for Coronary Artery Disease

Ying WANG¹, Hui-juan ZHU², Yong ZENG¹()

¹Department of Cardiology,
²Departement of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China

Received:2014-05-15 Online:2015-05-25 Published:2015-08-31

Abstract

CLC Number:

R394.5

Ying WANG, Hui-juan ZHU, Yong ZENG. Advances in Genomics Studies for Coronary Artery Disease[J].Acta Academiae Medicinae Sinica, 2015, 37(4): 475-481.

Figures/Tables 1

Table 1

Coronary artery disease-related genes by genome-wide association studies"

序号 Number	带 Zone		rs号 rs number		基因 Gene		风险等位基因 Risk allele	风险等位基因频率 Risk allele frequency		比值比 Odds ratio		相关的传统危险因素 Traditional risk factors
1	1p13.3		rs599839		SORT1		A	0.77		1.29		低密度脂蛋白、总胆固醇对他汀类药物敏感性、颗粒蛋白前体、脂蛋白相关磷脂酶A2 Statin sensitivity of low-density lipoprotein,total cholesterol,progranulin,lipoprotein-associated phospholipase A2
2	1p32.2		rs17114036		PPAP2B		A	0.91		1.17		-
3	1p32.2		rs11206510		PCSK9		T	0.81		1.15		低密度脂蛋白 Low-density lipoprotein
4	1q21.3		4845625		IL6R		T	0.47		1.04		免疫相关疾病 Immunity associated disease
5	1q41		rs1765637		MIA3		C	0.72		1.14		-
6	2p11.2		rs1561198		VAMP5-VAMP8-GGCX		A	0.45		1.05		-
7	2p21		rs6544713		ABCG5-ABCG8		T	0.30		1.06		-
8	2p24.1		rs2123536		TTC32-WDR35		T	0.39		1.12		-
9	2p24.1		rs515135		APOB		G	0.83		1.08		脂代谢 Lipid metabolism
10	2q22.3		rs2252641		ZEB2-AC074093.1		G	0.46		1.04		-
11	2q33.2		rs6725887		WDR12		C	0.14		1.17		-
12	3q22.3		rs2306374		MRAS		C	0.18		1.12		-
13	4q31.22		rs1878406		EDNRA		T	0.15		1.06		-
14	4q32.1		rs7692387		GUCY1A3		G	0.81		1.06		一氧化氮-环磷酸鸟苷通路关键酶 Key enzyme of NO-cyclic guanosine mono-phos- phate access
15	5q31.1		rs273909		SLC22A4-SLC22A5		C	0.14		1.09		-
16	6p21.2		rs10947789		KCNK5		T	0.76		1.06		-
17	6p21.31		rs17609940		ANKS1A		G	0.75		1.07		-
18	6p21.32		rs9268402		C6orf10-BTNL2		G	0.59		1.16		-
19	6p21.33		rs3869109		HLA-C,HLA-B, HCG27		G	0.55		1.14		三酰甘油 Triglyceride
20	6p24.1		rs12526453		PHACTR1		C	0.65		1.12		-
21	6p24.1		rs6903956		C6orf105		A	0.07		1.65		-
22	6q23.2		rs12190287		TCF21		C	0.62		1.08		-
23	6q25.3		rs3798220		LPA		C	0.02		1.51		脂蛋白a Lipoprotein a
24	6q26		rs4252120		PLG		T	0.73		1.06		-
25	7p21.1		rs2023938		HDAC9		G	0.10		1.07		-
26	7q22.3		rs10953541		BCAP29		C	0.80		1.08		-
27	7q32.2		rs11556924		ZC3HC1		C	0.62		1.09		-
28	8p21.3		rs264		LPL		G	0.86		1.05		脂蛋白代谢 Lipoprotein metabolism
29	8q24.13		rs2954029		TRIB1		A	0.55		1.04		-
30	9p21.3		rs1333049		CDKN2A,CDKN2B		C	0.47		1.37		平滑肌细胞增殖 Smooth muscle cells proliferation
31	9q34.2		rs579459		ABO		C	0.21		1.10		血栓形成 Thrombogenesis
32	10p11.23		rs2505083		KIAA1462		C	0.38		1.07		脂肪肝 Fatty liver
33		10q11.21		rs1746048		CXCL12			C		0.84		1.17	-
34		10q23.31		rs1412444		LIPA			T		0.42		1.09	血压 Blood pressure
35		10q24.32		rs12413409		CYP17A1, CNNM2,NT5C2			G		0.89		1.12	血压、颅内动脉瘤 Blood pressure,int- racranial aneurysm
36		11q22.3		rs974819		PDGFD			T		0.32		1.07	-
37		11q23.3		rs964184		ZNF259, APOA5-A4-C3-A1			G		0.13		1.13	高密度脂蛋白、总胆固醇 High-density lipoprotein,total cholesterol
38		12q21.33		rs7136259		ATP2B1			T		0.39		1.11	-
39		12q24.12		rs3184504		SH2B3			T		0.38		1.13	-
40		12q24.31		rs11066280		C12orf51			A		0.17		1.19	-
41		13q12.3		rs9319428		FLT1			A		0.32		1.05	-
42		13q34		rs4773144		COL4A1,COL4A2			G		0.44		1.07	-
43		14q32.2		rs2895811		HHIPL1			C		0.43		1.07	-
44		15q25.1		rs3825807		ADAMTS7			A		0.57		1.08	-
45		15q26.1		rs17514846		FURIN-FES			A		0.44		1.05	-
46		17p11.2		rs12936587		RASD1,SMCR3,PEMT			G		0.56		1.07	-
47		17p13.3		rs216172		SMG6,SRR			C		0.37		1.07	糖尿病 Diabetes mellitus
48		17q21.32		rs46522		UBE2Z,GIP, ATP5G1,SNF8			T		0.53		1.06	-
49		19p13.2		rs1122608		LDLR			G		0.75		1.15	-
50		19q13.32		rs2075650		APOE/TOMM40			G		0.14		1.14	-
51		21q22.11		rs9982601		SLC5A3-MRPS6-KCNE2			T		0.13		1.20	-

Table 1

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