载脂蛋白(a)基因多态性与冠心病研究进展

doi:10.3881/j.issn.1000-503X.2015.04.020

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (4): 482-488.doi: 10.3881/j.issn.1000-503X.2015.04.020

• Orginal Article • Previous Articles

Advances in the Association between Apolipoprotein(a)Gene Polymorphisms and Coronary Heart Disease

Li ZHU¹, Zhan LÜ¹, Yong-yan SONG²()

¹ Department of Cardiology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China

² Department of Medical Biochemistry,School of Basic Medicine,North Sichuan
Medical College,Nanchong,Sichuan 637000,China

Received:2015-01-30 Online:2015-05-25 Published:2015-08-31

Abstract

Abstract:

Human apolipoprotein(a)(LPA)gene is highly polymorphic,and the polymorphic loci on this gene include the Kringle Ⅳ subtype 2(KIV-2)repeat polymorphism,the pentanucleotide repeat(TTTTA)_n polymorphism,and a number of single nucleotide polymorphisms. KIV-2 repeat polymorphism was found to be significantly associated with coronary heart disease(CHD),and the reducing number of KIV-2 repeats is a risk factor for CHD. Both the increase and decrease of the pentanucleotide repeat(TTTTA)_n polymorphism repeats are possibly associated with CHD risk. In single nucleotide polymorphisms loci,the rs10455872 and rs3798220 loci were widely reported to be associated with CHD,while other loci were less reported. The association between LPA polymorphisms and CHD may be mediated by either the elevation of plasma LPA level or the change of LPA subtypes. This article reviews the association between the LPA polymorphisms and CHD and the underlying mechanisms.

Key words: lipoprotein(a), apolipoprotein(a), coronary heart disease, polymorphism

CLC Number:

Li ZHU, Zhan LÜ, Yong-yan SONG. Advances in the Association between Apolipoprotein(a)Gene Polymorphisms and Coronary Heart Disease[J].Acta Academiae Medicinae Sinica, 2015, 37(4): 482-488.

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