Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (5): 591-595.doi: 10.3881/j.issn.1000-503X.2015.05.017

• Orginal Article • Previous Articles     Next Articles

Effect of Selenious Yeast Tablets on the Thyroglobulin Antibody Level in Thyroglobulin Antibody-positive Patients with Differentiated Thyroid Cancer

Hui CONG1, Hui LI2, Jun LIANG3, Ke YANG2, Teng ZHAO2, Wen-sheng QIU1(), Yan-song LIN2()   

  1. 1Department of Oncology,the Affiliated Hospital of Qingdao University,Qingdao,Shandong 266003,China
    2Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    3Hematology and Oncology Center,Peking University International Hospital,Beijing 102206,China
  • Received:2014-10-24 Online:2015-10-15 Published:2015-10-31

Abstract:

Objective To investigate the change of thyroglobulin antibodies (TgAb) after the application of selenious yeast tablet (SYT) in differentiated thyroid cancer (DTC) patients with positive TgAb (>115 U/ml). Methods We enrolled 41 DTC patients with positive TgAb who had undergone total thyroidectomy and subsequent 131I therapy as well as applied SYT in group 1 (G1). Patients with an interval of more than 6 months between SYT use and 131I therapy or with repeated TgAb measurements before the use of SYTs were divided into group 2 (G2) and group 3 (G3),respectively. Changes in TgAb after application of SYT in both G1 and G2 were observed and analyzed by rank sum test. Comparison of TgAb gradient over certain time before and after the application was analyzed by t-test. Results The proportions of patients with decreased or elevated TgAb were 85.4% and 14.6% in G1 and 90.9% and 9.1% in G2,respectively. Compared with the previous TgAb levels,TgAb decreased significantly after the application of SYT in either G1 (P=0.000) or G2(P=0.003). In G3,the TgAb level rose by 5.6% every month before applying SYT and fell 8.3% every month after the application (P=0.086). Conclusion Application of SYT in DTC patients with positive TgAb can effectively decrease the TgAb level.

Key words: differentiated thyroid cancer, thyroglobulin antibodies, radioiodine therapy, selenium yeast tablets

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