Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2015, Vol. 37 ›› Issue (5): 612-617.doi: 10.3881/j.issn.1000-503X.2015.05.021

• Orginal Article • Previous Articles     Next Articles

Application of Reporter Gene Labeling in Stem Cell Therapy for Acute Myocardial Infarction

Xiao LI, Zheng-yu JIN, Yi-ning WANG()   

  1. Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2015-01-19 Online:2015-10-15 Published:2015-10-31
  • Supported by:
    Supported by the National Key Technology Research and Development Program of China(2012BAI23B06),the National Natural Sciences Foundation of China(81471725),and the Beijing Science Foundation(7142133)

Abstract:

Stem cell therapy for acute myocardial infarction is drawing great attention. However,the biological behavior and function mechanism of implanted stem cells remain controversial,as well as their clinical benefits. With the development of imaging probes and devices,molecular imaging enables noninvasive,dynamic tracking of stem cells in vivo. In this review,we summarize the use of various markers,especially the technique of reporter gene labeling,in the field of stem cell therapy,and highlight some recent preclinical and clinical achievements.

Key words: stem cell therapy, acute myocardial infarction, molecular imaging, reporter gene

CLC Number: