Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (1): 108-112.doi: 10.3881/j.issn.1000-503X.2016.01.020

• Orginal Article • Previous Articles     Next Articles

Research Advances in Molecular Mechanisms of the Invasion and Metastasis of Lung Cancer

Xian-zhong LIU1, Li-ting ZHANG1, Wei-quan TONG1, Shuai WANG1, Zhi-bo XU1, Fang CHEN2()   

  1. 1Department of Respiration,First Clinical Medical College,Zhejiang Chinese Medicine University,Hangzhou 310053,China
    2Department of Lung Function,First Affiliated Hospital,Zhejiang Chinese Medicine University,Hangzhou 310006,China
  • Received:2015-02-03 Online:2016-01-15 Published:2016-02-10
  • Supported by:
    Supported by the National Natural Sciences Foundation of China(81302934)and the Qianjiang Talents Plan of Science and Technology Department of Zhejiang Province(2012R10063)


The basic way of invasion and metastasis of lung cancer is that the tumor cells shed in the extracellular matrix,invade the basement membrane and the surrounding tissue,infiltrate into blood flow,and then survive and transport via the blood flow. After having been extravasated,migrated and arrested in the distant site,they finally form a metastatic lesion. Some basic mechanisms are required in these steps,such as tumor stem cells,diffusion and activity of tumor cells,escaping from apoptosis,angiogenesis and lymphangiogenesis,infiltration into blood flow,circulation and exudation,and distant metastasis proliferation. A better understanding of the mechanisms of the invasion and metastasis of lung cancer will facilitate the prevention and treatment of lung cancer.

Key words: lung cancer, invasion, metastasis, molecular mechanism

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