Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (3): 364-367.doi: 10.3881/j.issn.1000-503X.2016.03.023

• Orginal Article • Previous Articles     Next Articles

Transient Receptor Potential Melastatin 2:an Ion Channel for Oxidative Stress Sensing

Guang-chan JING, Meng-ren ZHANG()   

  1. Department of Traditional Chinese Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2015-05-18 Online:2016-03-15 Published:2016-06-10

Abstract:

Transient receptor potential (TRP) channel is a superfamily of cation channels located on the cell membrane. TRP channels are classified into seven subfamilies based on the amino acid sequence homology,and transient receptor potential melastatin 2(TRPM2) is the second member of the TRPM subfamily. More evidences have revealed the important roles of TRPM2 in physiological and pathological events such as release of insulin from pancreatic β-cells,inflammatory cytokines production from cells,and oxidative stress-induced cell death. As a cellular sensor for oxidative stress channel,TRPM2 is activated by a variety of factors. TRPM2 is a potential therapeutic target for oxidative stress-related diseases.

Key words: transient receptor potential melastatin 2, oxidative stress, Ca2+signaling

CLC Number: