Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (4): 378-382.doi: 10.3881/j.issn.1000-503X.2016.04.002

• Orginal Article • Previous Articles     Next Articles

Role of Thyroid Ultrasound in the Diagnosis of Thyroid Nodules with Atypia of Undetermined Significance

Qing ZHANG1, Qing-li ZHU1, Wen-bo LI1, Yu-xin JIANG1(), Zhi-lan MENG2, Ya-lan BI2, Yu ZHAO2   

  1. 1Department of Ultrasound, PUMC Hospital,CAMS and PUMC,Beijing 100730,China
    2 Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2016-05-09 Online:2016-08-20 Published:2016-08-20


Objective To evaluate the role of ultrasound for thyroid nodules with atypia of undetermined significance(AUS).Methods From January 2014 to December 2015,83 thyroid nodules with AUS diagnosed by ultrasound-guided fine-needle aspiration biopsy were collected from 1984 subjects. On the basis of ultrasonic features,each thyroid nodule was prospectively classified into one of three categories: low suspicion for malignancy,intermediate suspicion for malignancy,and high suspicion for malignancy. Results Among 83 lesions,19 lesions(22.9%) were confirmed malignant,8 lesions (9.6%)were benign,56 lesions (67.5%)had no abnormal changes during clinical follow-up. The nodules were solitary in 36 cases (43.4%)and multiple in 47 cases(56.6%).The maximum diameter was (1.2±0.7)cm. Based on the ultrasonic feature of 19 malignant cases,16 cases (84.2%) were classified as high suspicion for malignancy,2 cases(10.5%) as intermediate suspicion for malignancy,and 1 case(5.3%) for low suspicion for malignancy. Univariate and multivariate analyses revealed that the degree of malignancy of thyroid nodules was significantly associated with ultrasound image classification[OR=9.23(2.96-28.79),P=0.00],but not with age,gender,nodule number,and nodule size (all P>0.05).Conclusion Ultrasound diagnosis by using the present thyroid ultrasound classification system can be helpful for distinguishing malignant and benign AUS thyroid nodules.

Key words: ultrasonography, Bethesda system, ultrasound-guided fine-needle aspiration biopsy, thyroid nodules

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