Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica

Acta Academiae Medicinae Sinica ›› 2016, Vol. 38 ›› Issue (4): 480-483.doi: 10.3881/j.issn.1000-503X.2016.04.020

• Orginal Article • Previous Articles     Next Articles

Role of Exosome Shuttle RNA in Cell-to-Cell Communication

Wei ZHANG, Peng PENG, Keng SHEN   

  1. Department of Obstetrics and Gynecology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
  • Received:2015-07-06 Online:2016-08-20 Published:2016-08-20
  • Supported by:
    Supported by the Youth Fund of National Natural Sciences Foundation of China (81101976,81441076)


There are several ways that transpire in cell-to-cell communication,with or without cell contact. Exosomes play an important role in cell-to-cell communication,which do not need cell contact,as that can result in a relatively long-distance influence. Exosome contains RNA components including mRNA and micro-RNA,which are protected by exosomes rigid membranes. This allows those components be passed long distance through the circulatory system. The mRNA components are far different from their donor cells,and the micro-RNA components may reflect the cell they originated. In this article we review the role of exosomes in cell-to-cell communication,with particular focus on their potentials in both diagnostic and therapeutic applications.

Key words: exosomes, exosome shuttle RNA, mRNA, microRNA

CLC Number: